Gene: Dopamine Receptor D4 (DRD4)
DRD4 is involved in signaling in the brain in an
area that is responsible for regulating emotion
and behaviors. The D4 subtype codes for a
protein that inhibits a regulatory enzyme called
adenylyl cyclase. The mutations in the gene is
linked with neurological conditions such as
autonomic nervous system dysfunction and
ADHD.
https://www.ncbi.nlm.nih.gov/gene/1815
Location
This gene is located in chromosome 11 at
position 15.5. Its molecular position is from
base pairs 637,305 to 640,706, which
shows that the gene has 3401 nucleotides
including the introns and exons. There are
four exons in the gene according to our
program.
https://www.ncbi.nlm.nih.gov/gene/1815
Exons
Exon 1:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVS
VATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEV
E1-Gene: start-1 length-288
Exon 2: QGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDR
E2-Gene: start-2132 length-111
Exon 3:
FVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRD
YVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPP
APRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCG
SNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVG
E3-Gene: start-2345 length-660
Exon 4:
AFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVF
RKALRACC
E4-Gene: start-3099 length-198
1 ATGGGGAACC GCAGCACCGC GGACGCGGAC GGGCTGCTGG CTGGGCGCGG 50
{M G N R S T A D A D G L L A G R G
51 GCCGGCCGCG GGGGCATCTG CGGGGGCATC TGCGGGGCTG GCTGGGCAGG 100
P A A G A S A G A S A G L A G Q
101 GCGCGGCGGC GCTGGTGGGG GGCGTGCTGC TCATCGGCGC GGTGCTCGCG 150
G A A A L V G G V L L I G A V L A
151 GGGAACTCGC TCGTGTGCGT GAGCGTGGCC ACCGAGCGCG CCCTGCAGAC 200
G N S L V C V S V A T E R A L Q T
201 GCCCACCAAC TCCTTCATCG TGAGCCTGGC GGCCGCCGAC CTCCTCCTCG 250
P T N S F I V S L A A A D L L L
251 CTCTCCTGGT GCTGCCGCTC TTCGTCTACT CCGAGGTGAG CCGCGTCCGG 300
A L L V L P L F V Y S E V}
301 CCGCACGAGC ATCCTCACCT GCTCCTCGGT TCCCCGTCCC TGTCCCTACG 350
351 GAGGACCCGG CGCGACCCGG CCCCTTTCTG GTGCGGAGCT TCCAGCTGGG 400
401 GCGGCGGCAG GGGCGCTGCG CCTTGTCCCT CGGCGATACA CCCACCGCCG 450
451 CCACCTCGCG ACCTTCCACC CGCTGCGCTG TCTGTCCCCC GACCCTCGTT 500
501 CCTCTTCTCC TTCCCCGTCT GTCTTGGCGT CTGTTATCCA GGAGATGCCC 550
551 GTCCTTCTAT CCAGGGACCC CGGAAACAGG CGACTTTGTC AAGCCCAGTC 600
601 CCCTCCGTAG CTGGATTTCA CCTCCAGGGC AGCCAGCTGG ACAGACAGGC 650
651 AGATGCAGGC TCAGCCCCCT GGCTGCCGTG GGACACACAC ACACACACAC 700
701 TGCCACAGCC ACTGCCCACC ACACACACCT AGTGCAGATG CTGGCACACC 750
751 CCCAGAAGGA GGCTCACAGC TCGCAGGGGA GACCTGGGCT GGACAAAACC 800
801 CAGGGGAGGG GAGGGTGTGT GGGGACCAGG CCCCTGCTGA GAACCCTGGG 850
851 GGGAAGCCTG AGGGGGAATT GGGGGATGGA GCCCACACTC CACACCAGGT 900
901 CTGGCCCTCG AGTGGGTCGG CCTTGGTGCC AGCCCCTCTG CGGCCAGAGA 950
951 AAAGCAGCTT AGGGCTGAGC TGGAGACGCG GTGTCCCCGA CTGTGGGGGA 1000
1001 GGGGGACTCG AGGTTTCCCC TTGATGGACA CAGTGAATCC AGGCGGCTGG 1050
1051 GGCAGAGACC AGCAGCACGG GACACGCGTG ACCTGTGCTC CTTTCGAGCC 1100
1101 GCAGACGTCA CAGTGACGAC GTTTAAGCTC CTAATCTCCC CAAATCGGCG 1150
1151 GGAAGGATTA GAGGGGCTGC CTGCTCCTTT GCCCTTGGAG AGAGTCACTC 1200
1201 CACGTGGAGT CCTACGCTGG GCACTGGGCA CGGTCTTCAT ATTTTTAATT 1250
1251 ATAATTTATC TTCAAGACAA TTATGATGTG GATACTATCA TCACCCTTGT 1300
1301 CTTACAGATG AAGAAACAGA AATGAATTAA CGTGCCCGAG TCTCCCACAG 1350
1351 AGAACTTAGC CAACAGAGCA GCCAGCTTCG CTTCTAGGCC CAGCGGGGAC 1400
1401 CCTGCCTACC CCAGGCTGGG GAGGGGCTCC CTTTGAGCCC GATGATATCA 1450
1451 GGCCCGCCCC CAGGGAATTC CCCAGGCCGT TCTCATGTTT GTAACAAAAG 1500
1501 GGAGACCAAG GCCAGAAGCC GTGATTCACG CCTGTAATCC CAGGACTTTG 1550
1551 GGAGGCAAAG GCAGGAGGAT AGTTTGAGAC CAGCCTGGGA AACATACCAG 1600
1601 GCCTGGTCTC TACAAAAAAT TTTAAAATAT CAGCCGGGGG TGGTGGCTGC 1650
1651 GGCTGTTGTC CCAGCTATTC GGGGGAGCTG AGGCGGCAGA ATCGCTTAAA 1700
1701 CCTGGGAGGC GGAGGTTGCA GTGAGTTGAG ATCTCACCAC TGCACTCCAG 1750
1751 CCTGGGCAAC AAGAGCGAAA CTCCGTCTCA AAAAACAAAA AGAAAAACAA 1800
1801 ATCAGCCGGG GGTGGTGGCG CGCGGCTGTA ATCCCAGCTA CTCTGGAGAC 1850
1851 TGAGGTGGGA GGATCGCTTG AGCTCAGGAA TTCCAGGCTA CAGTGAGCCA 1900
1901 TGATGGAGCC ACAGCACTCC AGCCGCGGTG ACACAGCGAG ACCCTAACTC 1950
1951 AAAACAAAGG GAGATCTGCG TGGGGAAGGG GTGTTTCCCT GCCCGGTCCT 2000
2001 CTGGCCTCTG GCTCACAGCC GGGCCCCCTT CTCCGTATTC AGCCCTGGAA 2050
2101 CCTCAGGGCC TGTGGTGTCG CCGCGCAGGT CCAGGGTGGC GCGTGGCTGC 2150
{Q G G A W L
2151 TGAGCCCCCG CCTGTGCGAC GCCCTCATGG CCATGGACGT CATGCTGTGC 2200
L S P R L C D A L M A M D V M L C
2201 ACCGCCTCCA TCTTCAACCT GTGCGCCATC AGCGTGGACA GGTGCGCCGC 2250
T A S I F N L C A I S V D R}
2251 CCTCCCCGCC CGCGCCCCGG CGCCCCCGCG CCCCGCCCGC CGCCCTCACC 2300
2301 GCGGCCTGTG CGCTGTCCGG CGCCCCCTCG GCGCTCCCCG CAGGTTCGTG 2350
{F V
2351 GCCGTGGCCG TGCCGCTGCG CTACAACCGG CAGGGTGGGA GCCGCCGGCA 2400
A V A V P L R Y N R Q G G S R R Q
2401 GCTGCTGCTC ATCGGCGCCA CGTGGCTGCT GTCCGCGGCG GTGGCGGCGC 2450
L L L I G A T W L L S A A V A A
2451 CCGTACTGTG CGGCCTCAAC GACGTGCGCG GCCGCGACCC CGCCGTGTGC 2500
P V L C G L N D V R G R D P A V C
2501 CGCCTGGAGG ACCGCGACTA CGTGGTCTAC TCGTCCGTGT GCTCCTTCTT 2550
R L E D R D Y V V Y S S V C S F F
2551 CCTACCCTGC CCGCTCATGC TGCTGCTCTA CTGGGCCACG TTCCGCGGCC 2600
L P C P L M L L L Y W A T F R G
2601 TGCAGCGCTG GGAGGTGGCA CGTCGCGCCA AGCTGCACGG CCGCGCGCCC 2650
L Q R W E V A R R A K L H G R A P
2651 CGCCGACCCA GCGGCCCTGG CCCGCCTTCC CCCACGCCAC CCGCGCCCCG 2700
R R P S G P G P P S P T P P A P R
2701 CCTCCCCCAG GACCCCTGCG GCCCCGACTG TGCGCCCCCC GCGCCCGGCC 2750
L P Q D P C G P D C A P P A P G
2751 TTCCCCGGGG TCCCTGCGGC CCCGACTGTG CGCCCGCCGC GCCCAGCCTC 2800
L P R G P C G P D C A P A A P S L
2801 CCCCAGGACC CCTGCGGCCC CGACTGTGCG CCCCCCGCGC CCGGCCTCCC 2850
P Q D P C G P D C A P P A P G L P
2851 CCCGGACCCC TGCGGCTCCA ACTGTGCTCC CCCCGACGCC GTCAGAGCCG 2900
P D P C G S N C A P P D A V R A
2901 CCGCGCTCCC ACCCCAGACT CCACCGCAGA CCCGCAGGAG GCGGCGTGCC 2950
A A L P P Q T P P Q T R R R R R A
2951 AAGATCACCG GCCGGGAGCG CAAGGCCATG AGGGTCCTGC CGGTGGTGGT 3000
K I T G R E R K A M R V L P V V V
3001 CGGTGGGTTC CTGTCCTGAG GGGCGGGGAG GAGAGGAGGG GGGGGGTACG 3050
G}
3051 AGGCCGGCTG GGCGGGGGGC GCTAACGCGG CTCTCGGCGC CCCCAGGGGC 3100
{A
3101 CTTCCTGCTG TGCTGGACGC CCTTCTTCGT GGTGCACATC ACGCAGGCGC 3150
F L L C W T P F F V V H I T Q A
3151 TGTGTCCTGC CTGCTCCGTG CCCCCGCGGC TGGTCAGCGC CGTCACCTGG 3200
L C P A C S V P P R L V S A V T W
3201 CTGGGCTACG TCAACAGCGC CCTCAACCCC GTCATCTACA CTGTCTTCAA 3250
L G Y V N S A L N P V I Y T V F N
3251 CGCCGAGTTC CGCAACGTCT TCCGCAAGGC CCTGCGTGCC TGCTGCTGAG 3300
A E F R N V F R K A L R A C C}
3301 CCGGGCACCC CCGGACGCCC CCCGGCCTGA TGGCCAGGCC TCAGGGACCA 3350
3351 AGGAGATGGG GAGGGCGCTT TTGTACGTTA ATTAAACAAA TTCCTTCCCA 3400
3401 AA 3402
Map of Gene
