MCM6

Gene

- Located on Chromosome 2

- Remains essentially the same after

generations of evolution

- Codes protein (MCM) that splits DNA into 2

strands during DNA replication

- Regulates gene that codes for lactase

(Mutations can result in lactose intolerance)

Overview

Exon 1

1 AAGAGGGGGC GGGGCGGAAG CGGCGGCGGC GCGCGCAAAG CTGCAGCGTC TGGAAAAAAG CGACTTGTGG CGGTCGAGCG 80

81 TGGCGCAGGC GAATCCTCGG CACTAAGCAA ATATGGACCT CGCGGCGGCA GCGGAGCCGG GCGCCGGCAG CCAGCACCTG 160

{M D L A A A A E P G A G S Q H L

161 GAGGTCCGCG ACGAGGTGGC CGAGAAGTGC CAGAAACTGT TCCTGGACTT CTTGGAGGAG TAAGTCGGCG AGCGCCCCGG 240

E V R D E V A E K C Q K L F L D F L E E}

241 GCCTCGCCCG CCTCCGGAGC CTGCGGCGTC TGGGCCAGGC GGTGCCGTGT GGGCGGCGGG TGTTCCGGAA CCTGGGGGTC 320

321 GCGCGTCCGG GAAGCGCCTC CCCGCCCGCC CCCCAACTTT AGGCTCCGAG CCCGGCGGCC GCGAGGAGCC TGGGACAGGC 400

401 TGGGTTTTTC TGGAGTAAAA CCCATCTCGA GCCCTAAGAC GCTCGTGCCC AGTGCTCAGC GCTTTGCTTC TGTCACTTGA 480

481 TGCTCACCAC CCCGCGAGCC TGGTATTTGC ACAGCCCTCG GTGACCGGCG CGGAAACCTG GGCTCGCTGA GTATAGTAAC 560

561 TGGGCCGCTG GGTGCGGCCA GGTCGAGTGG GAGGCCGAAG TGCCATTGAA TCTCGTCGGT GCCCTGCTGG GCCACGCAGC 640

641 CGGGAGCATG GTGCTGGGGG TTCGCAGGGC ACGGGCCACC CTCGCCTCTT GTGCTGATGA AAGTTTCTGC GTCAACTGTG 720

721 GTTTGAAAGC TGCTGGGGGG CGGAGCCCTG CCCTGCAGAG AGTAGCTCAC CATATCCCTT CTTCTGGGTC CCTTGCTCCC 800

801 CTTTCCCTCT GGCCTTCCTT TCCTTTCTCT ACTCTTCTTT TTTTCTGTGC CTCTGGGCTC CTAGCTTCAT AACCCCAACC 880

881 TCCTCCCTGG CTTGCCTCAC CCACCGGTTA TTTTTCCTGG AGCAGATACA CCACGGCCTC CAGGATGAAG GGTCAGCAGT 960

961 TTGGAATGGC TTTTGAAGTT CTTTTTTAGT AAAATATACA TAACAAAGTT GACCATTTTA GCCATTTTTA AGTGTAGAGT 1040

1041 CCAGTGGCAC TAAGTGCATT CACCTCGTTG TGCAGCCGTC ACCACTCTCC CATCTCCAAA CTTTTTTTTT TTTGAGGCGT 1120

1121 AATTTAGCCC TTGTTGCCCA GGCCGGAGTG CAGTGTCACC ATCTCAGCTC ACCGCAACCT CCGTCTCCCG GGTTCAAGCT 1200

1201 ATTCTCCTGC CTCAGCCTCC CTACTAGCTG GAATTACAGG CATGCGCCAC CACGCCCGGC TAATTTGGTA TTTTAGTAGA 1280

1281 GATGGGGTTT CTCCATGTTG GTCAGGCTGG TCTTGAACTC CCGACCTCAG GTGATCCCCC CGCCTGGGCT TCCCAAAGTG 1360

1361 ATTACAGGCG TGAGCCACCG TGTCCGGCTC CAAACTCTTT TCATCTTCCA AACTGACATT CTGTGCCCAT TAAACACGAA 1440

Exon 2

2881 AGAAATTGAT TTTTTCTTAA GGCGAATCTG CATATTATGT TTGAAAGAAC AGAAATAAAT TTGTATGATA TCCTGCTTGG 2960

2961 GCTTTAGAAG CAAAAATACC AGCAGCTTTA TTTAGTGTGC CTGTTTCAAT TTTCCCGAAG TCTTGGGCTG TGAAACACCT 3040

3041 CATTTCCATG TATTCTTATT TCTGTTCTGC TTCTTAAATC CCTGACTAAT TTGTTAGTTT GCAAATTCCC TACAGAAATG 3120

3121 GAATCATTGG GTTTGAGACT GAATTTCTTG ATTTAACATT TTCCAATCTT AATTATACAT GACAGTAGTA AAAGAAGAGT 3200

3201 TAGTTGTTGG GTTTTTTTGT TAGTTAGCAG TTAAACCTCA CAATCATGGT GGAAGGCAAG GAGGAGCAAG TCACTGATGT 3280

3281 CTTACGTGGA TGGCATCAGG CAAAGAGAGC TTGTGCAGAG GAACTCCTCT TTTTAAAACC ATCAGATCTC GTGAGACTTA 3360

3361 CTATCAGAGA ACAGCAGGGG AAAGACTTGT CCCCATGCTT CAATTAACTC CCACCAGGTG CCTCCCACAA CATGTGGAAA 3440

3441 TTCAAGTCGA GATTTGGGTG GGGACACAGC CAAACCATAT CAGAAGGGAG GAGTAACTTG CCCCAAGTTA CAGAACTGCC 3520

3521 AAACATGGGC CTGTCTGAGC CTAGTTGTTG GACTTTAACC AATGTTCTGA ATTATCATTC AGGTTCTTTG TACTGCCTGT 3600

3601 GTCCTTAATC TAGTTGACTC GAATGTACCT GCAGGTTTCA GAGCAGCGAT GGAGAAATTA AATACTTGCA ATTAGCAGAG 3680

{F Q S S D G E I K Y L Q L A E

3681 GAACTGATTC GTCCTGAGAG AAACACATTG GTTGTGAGTT TTGTGGACCT GGAACAATTT AACCAGCAAC TTTCCACCAC 3760

E L I R P E R N T L V V S F V D L E Q F N Q Q L S T T

3761 CATTCAAGAG GAGTTCTATA GGTATGGGCA TATTAATCTT CTTTACTTTG AATAGGGGTT GAAATCCGGG AAGCCAGCTC 3840

I Q E E F Y R}

3841 TTCTTGGACT GTAAGTGTTC ACTTGTGTAG CAGAAGGTCA GCTTTCACAG TTATTTCCCA CTGAGAAGAG GCGCTTTGAT 3920

3921 ACTGCCAGTG GTCGTTTTAG TACTGCTCTG AACTTCATGT AGGCCTTTGT AGAGCCGAAC GTTTTTTTGT TGTTGTGTTT 4000

4001 TGTTTGTTTG TTTGTTTGTT TGTTTTTTGA GACGGAGTCT TGCTCTGTCA CACCTAGGCC GAAATGCAGT GGCGCGATCT 4080

4081 TGGCTCACTG CAACCTCTGC CTCCCGGGTT CAAGCGATTC TTCTGCGTCA GCCTCCCGAA TAGCTGGGAT TACAGGCGCC 4160

4161 CACCATCACG CCCGGCTAAT TATTTACATT TTTTAATAGA GACGGGGTGT CACCATGTTG GTCAGGCTGG TCTCGAACTC 4240

4241 CTGATCTCAG GTGATCCGCC CGCCTCGGCC TCCCAAAATG CTGGGATTAC AGGCGTGAGC CACCGTGCCC GGCCAGAGCT 4320

Exon 3

5761 TCATAAACAG CCCACAGAAA ATTCACAGTA TTGAGCATAA TATTGACAAG ATGATTGTTC AGCTAGTCAT CTTGGACAGA 5840

5841 GGAATGGCCA ACAGTGTGGG TGCTGTATGA TTATTTATGT GCTATATGAT AATCAGGTAT GGTATGACAT TTTATATTTA 5920

5921 GTGTTCCGGT GGGATAGGAG AGAACTGAAA GAGGGTCCTA AACCTAGAGT AGATAATAGA AGTGTCCTAC ACAGTTAAGT 6000

6001 TCTAAGGTTT AGTTGTAACC AGATGAAATT CCTTAATCTC GGCTGTTGGT AGGTATGTAA AGGGAAGGAG GCCTTGGTAA 6080

6081 ACCTCTAAGG TATCAGCTGA CTTTTTTGTT TTTCAGAGTT TACCCTTACC TGTGTCGGGC CTTGAAAACA TTCGTCAAAG 6160

{V Y P Y L C R A L K T F V K

6161 ACCGTAAAGA GATCCCTCTT GCCAAGGATT TTTATGTTGC ATTCCAAGAC CTGCCTACCA GACACAAGTA AGAAACCCTT 6240

D R K E I P L A K D F Y V A F Q D L P T R H K}

6241 CTCTGGAAAA AAAGGAATTC ACCAAATGGT ATAAGTACCA CTTAGCTGAC AGTCAGAAAA CTTGAGAGGT TGCCTTGATC 6320

6321 TGCTATTAGC TGGCTATTTA ACATTATACA AATCACTTTT ACCTCCCTGA GCCTCAGTTT CCTTGTCTGT GAAGTCTTTT 6400

6401 GGCTTAGGTT TTCTACCTAA ATCATGCAAA AAATAGGTTT GTTGCTGTAA AATTACTTTT TCATAATTGA TAATCACAAT 6480

6481 AATTATAAAA CAAGTACTTA TAAAATTGAT GCTGTAAAAT ACCAGGAGGA AAAAATAGTG GTTTGCATTC AGATTTTGTA 6560

6561 GAAGGTTGAC TTTTGTAGGA GTTATACCCA CTTATCCAGA AAGTTTAGTG TTGGAGAAAT GTATTTTCCT ATGGAGATGG 6640

6641 GATTAGATGT AAAGGGAGTG AAGCAAATTT TTAGGATTAT CACATTTTAG GGCGCCTTTT AGGGAAATTT GGGAGAAAAT 6720

6721 TGATCAAGGG AGAAAATATG AAATTCTAGA AATTCCTGAA TCTCTGGAAA TTTTTGTTGG TTTAAATGCA TAATTTTCAA 6800

6801 ACACCCCTTT GGCAGTTATT TTAAGAATAA ATTTACTGGA TAAAATTGAA GTGATATTTT GAAAAGTTAA ACTACTGAAA 6880

6881 TTATAAAATT ACCAAATTAC TTCACATAAA ATGGGTTTGT AAAGGAAGTG TTTCTGAACT TTGAGTACAA AATTTTTTCT 6960

6961 CATGATAGGA TTATTATGTA ACACATGCTT TTTTTTTTAG AAATTGCGGG TAAGCAAAAA AGTATTTGCA TATAAAACAA 7040

7041 AAACAGGATC ATTCTGTTTT TGTTTTTTTT TTTTTCTGAG ACAGAGTCTT GCTCTGTCAC CCAGGCCAGA GTGCAGTGGC 7120

7121 ACGATCTTGG CTCACTGCAC CCTCCACCTC CCGGGTTCAA ACAATTCTCC TGCCTCGGCT CCCCGAGTAG CTGGGATTAC 7200

Exon 4

7201 AGGCGCCCGC CACCACGACT GGCTAGTTTT TGTATTTTTA GTAGAGGTGG GGTTTCGCCA TGTTGGCCAG GATGGTCTTG 7280

7281 ATCTCTTGAC CTCATGATCC GCCCACCTTG GTCTCCCAAA GTGCTGGGAT TACAGGTGTG AGTCACTGCG CCCAGCCCGT 7360

7361 TCTGTTTTAT AATTTTAATT TTCATTTTTT TGGCATCCTT TAGTTCATTT ATATATTTTG TTCTGGATAC ATATACGTCA 7440

7441 TATAATTTAG GATTGGGCAC GTTGACTAAA TTATTCTTAT AGGAGAGTCC AAAGAATACC TTGTCTCTTG AATTTTTTTT 7520

7521 TTAAACATAA ATTATCTTTG AATACCCTCT CACTAAAATG GAAAGATTCT TAGTTAAGAG ATGAATGTTT ACTAATGGGA 7600

7601 CATTTGTCTT TAAACAGGAT TCGAGAGCTC ACCTCATCCA GAATTGGTTT GCTCACTCGC ATCAGTGGGC AGGTGGTGCG 7680

{I R E L T S S R I G L L T R I S G Q V V R

7681 GACTCACCCA GTTCACCCAG AGCTTGTGAG CGGAACTTTT CTGTGCTTGG ACTGTCAGAC AGTGATCAGG GATGTAGAAC 7760

T H P V H P E L V S G T F L C L D C Q T V I R D V E

7761 AGCAGTTCAA ATACACACAG CCAAACATCT GCCGAAATCC AGTTTGTGCC AACAGGAGGA GATTCTTACT GGATACAAAT 7840

Q Q F K Y T Q P N I C R N P V C A N R R R F L L D T N

7841 AAATCAAGAT TTGTTGATTT TCAAAAGGTA TTTATTTAAC ATCTGTTTAG ATCAGAGTCC ATCTATGATA ATAATTCACT 7920

K S R F V D F Q K V}

7921 TCTAGGCCCT TGCAATAGCT TATTTAGATA ATGTTCAACT CAATTTTTAT GTAAGTTAAG CATCATCAAA ATGACTACAA 8000

8001 AGTTAAGCCC AAAACTGTTC ATGTAAATTA TAATTGTTAG TATATACATT TGTTTTAACT TTCAGTAACT TGGAAGTTCC 8080

8081 TTAAGACTGA CAAGATGTAT TTGTCAAAGA ATAAATGGTA ACTAGGTGGT GGTGGTTGTC ATTATGAACT GGAGTTAAGA 8160

8161 AAACTTAAAG AAATAGCAAC TTGTTAGTGT AAGATTTCCA TTTGCTGCAT AGAAAGGAAA GCATGAATAG GACAGGCTAG 8240

8241 CTTGGAAGCA ATGAGGATTA TCATGATTGA AGTAAAGGAG CCAAATTGGA GATCATCTGA GAGATGATTT GATGTGAGAC 8320

8321 CTGGAGGTAC TTGGATCCCT AAATCTTAGG CTGAGGAGTT TGAGCCTATC TTAATAAGCA GTGGGAATAT AGTGGGAAGG 8400

8401 TAGTTTGTGT GTGTGGGTGT GTGTTTGTTT TGTTTTGTTT TTTGTTTTTT TTTGAGACAG TCTCTCTCTG TCACCCAGGC 8480

8481 TGGAGTGCAG TGGCGCGATC TCGGCTCACT GCAAGCTCCG CCTCCTGGGT TCACGCCATT CTCCTGCCTC AGCCTCCCGA 8560

8561 GTAGCTGGGA CTACAGGTGC CCACCACCAC ACCCGGCTAA TTTTTTGTAT TTTTAGTAGA GACAGGGTTT CATCGTGTTA 8640

Exon 5

8641 AACCAGGATG GTCTCGATCT CCTGACTTCG TGATCCGCCT GCCTCTGCCT CCCAAAGTGC TGGGATACAG GCGTGAGCCA 8720

8721 CTGCACCCAG CCTGTGTGTT TTTTTTTAAA AGCAAACTGA ATAAGTCCGT GATGGGTTTA ACAGAGGGTA ATAGGCAATT 8800

8801 TCAGTTACCT GGGCAAGAGG TGATGGATGG CAGTAGTAAG AATGAAGGGG ACCCTCAGAT TTCAGCAGGA CTTAATTTTA 8880

8881 TGGGACATAC AAAATGGAAA GAAAAGCTGA AGCAGCTCAA GTATGGAATA ATTATTATCA GATGAATTTA ATATTATTTA 8960

8961 TATTGCTCTG ATAATCATTC TCCTTATTTG GCTTTCTTAC ATTAACCTGG TAGCTTATAA GATGCACATA TTTTACCAAC 9040

9041 AGCTTTGGGT AGGAGATGTC TTATCTTATA AAGTATGAAT CTAGATTGGG TCTTAGTTTG GGGGGGGGAA CACAACTGTA 9120

9121 TAAAGGACAC TCTTGACAAG ACATTTGAAG ATGGACTAGA TAATAGAAGA TATGTAATTT TATGAAATTA AATATTGTTT 9200

9201 AATTATCTTG GTTGTGATAA TGATATTGTA ACAGGATTGT CTTTATTCTT AGAGATGAAT GCTAAAATAT TTAGGTATGA 9280

9281 AGTTTCTTGA TGTTCACAAC TGTGTTCAAA TACATAGTAA AAAAACATGT ATCTGTAAAT AATGTTAGCA GTTGTGTTGA 9360

9361 AGTGGAGGGT ATAAAAGGTG TATTTGAAAT TTTCTGTAAA ATTATCTTAA AGCTTAGGAG AAGATGGAGC ATGGAACAGA 9440

9441 TATTTGGAGT CATTTTGAAC AAAGAAAAAA ATTATTTTTT AATGAGTAAA AGTGAAGTTT TTTTTTTCTC TGCTGCTTGA 9520

9521 ATCATCATGG AGTTTTTAAA TAGATGTAAT CTCTTGCCAA ATTGAACTAT TTGACTAAAA GGAGTTTTAG AGTAGATAAT 9600

9601 TTTTAGGATA AATGTTGGTA CATGTGAAAA GTCTGCTAAT GGGTCAGATA GTTTAGAATA CGTCCGTATT TGTGGTATTT 9680

9681 AATTTAGATT ATATGGCATC TGAAAGGTAT TGCTTCTCAT TCTTGGTTGG TTGTTTGTCT GTATTACAGG TTCGTATTCA 9760

{R I Q

9761 AGAGACCCAA GCTGAGCTTC CTCGAGGGAG TATCCCCCGC AGTTTAGAAG TAATTTTAAG GGCTGAAGCT GTGGAATCAG 9840

E T Q A E L P R G S I P R S L E V I L R A E A V E S

9841 CTCAAGCTGG TGACAAGTGT GACTTTACAG GGACACTGAT TGTTGTGCCT GACGTCTCCA AGCTTAGCAC ACCAGGTCAG 9920

A Q A G D K C D F T G T L I V V P D V S K L S T P G}

9921 TAATCTGTGG CTCAAATTTA ACAAATTCTC AGTTACCTAA ACTGCACAGT ATCTAGCTTC CCACATCTTC ATTGTCTTCT 10000

10001 TTTTGGCTAC CAATCAGAAG CTGAGGAACG AAGTGTGATG AGAATAAAAA CAAATTGGTT TTGCCACAAA TGGTGCTATT 10080

Exon 6 & 7

10161 TAATATTTAA GTTGTGAAAC AACCTATCAT TCTGTTTCAG GAGCACGTGC AGAAACTAAT TCCCGTGTCA GTGGTGTTGA 10240

{A R A E T N S R V S G V D

10241 TGGATATGAG ACAGAAGGCA TTCGAGGACT CCGGGCCCTT GGTGTTAGGG ACCTTTCTTA TAGGCTGGTC TTTCTTGCCT 10320

G Y E T E G I R G L R A L G V R D L S Y R L V F L A

10321 GCTGTGTTGC GCCAACCAAC CCAAGGGTCA GTCGTTTTGG GGGTTTTTGT TTGTTTTTGA AACAGTCTCT CTCTGTCACC 10400

C C V A P T N P R}

10401 CAGGCTGGAG TGCAATGGCA AAGTCATGGC TCACTGTAGC CTCCACTTTC TGGGCTCAAG TGATCCTACC ATCTCAACCT 10480

10481 CCTGAGTAGC TGGGATTATA GGTGTGAATC ACTGCACCCA GCTAATTAAA AAAACTTTTT TAGAGATGAG GTCTTGCTCT 10560

10561 GTTGGCCAGG CAGGCCAACA GTGAGTCTTA GTAGAGTGAC AGCTTAAGAA ACACCTACCC TGAGCTGCCA CGAAATGATA 10640

10641 GGATTCTGAA ACATCTGGGC TGTCTCATCA ATGTTGAGAG CACGGGATGG GGTTAAGATT TGATGAGTTT TAAAACCAAA 10720

10721 TCTTTTGACG TATGCCTTTC TGATCTTGAA AAAAAGTCTT ATTTGATGTC TTACATAAAA GCTCAATGCT TTTAAGTGCA 10800

10801 GTGGTACAAA TTATCCACGC TGTTTTTTGT TTTAAAGTTT CATAGTTCCT CTGTTATTCT TCTGGAGGAA ATACAAATAA 10880

10881 AAAGATTTAG TAATCTGGGA AGTAAACTTC TGAGAATGAT GAACCCCTGG CAGTATCATT CAGTTAACTT GATTCTGTGT 10960

10961 CATAAATGGG AGTTTGGAAA ATAGTTCAGT ATTGGAAAAA GGGAGTGAAC ATAATATTCT CTTATTTTAT TTGCATCTTT 11040

11041 ATGTCAGTGA TTAACATTCT GCTATCGCTT ATCTCTTGAG CATTCAGGTA GCTTTTTTTC TATTTAACTC ACTGGACAAA 11120

11121 TGACATACCC TTAAGTGTCT TTGTTAACTG AGGGCTTACT AGTTTGGGGA GTTGTTTTTT TTTAAACCTT TACAGTCAAT 11200

11201 AAATTGTGAG GTTGACTTCC CATGCTATGT TGTGTTTGTA ATGAAGTTTC TTCTCCTTTA TGCTCTTTTG ACTGCTTCTA 11280

11281 TACTAATGAT TCTTCCTTTG TTCTCTACCA TTAGTTTGGG GGGAAAGAGC TCAGAGATGA GGAACAGACA GCTGAGAGCA 11360

{F G G K E L R D E E Q T A E S

11361 TTAAGAACCA AATGACTGTG AAAGAATGGG AGAAAGTGTT TGAGATGAGT CAAGATAAAA ATCTATACCA CAATCTTTGT 11440

I K N Q M T V K E W E K V F E M S Q D K N L Y H N L C

11441 ACCAGCCTGT TCCCTACTAT ACATGGTAAG AATTCCATCC ATTTGTACCA TAAACTTGAA ATCAAAATAA TGATTATAAA 11520

T S L F P T I H G}

Exon 8

12961 CTGGGCTCAA GCAATCCTCC CGCCTTGGCC TTCCAAAGTG CTCGGATCTT CCAGAGTGAT CAGATTACAG GCATAAGCCA 13040

13041 CCACACCCAG CCTAATTTTC TGCTTTAAGG AATGCCTTGT GTAACTTTGC ATAGCACTTT GTTGATGGAG TTCAGAGAGT 13120

13121 CGACAGTTCC ACAGAAAAAT GTTTCTTTTA ATAGCACAGT GTTCTTTTTT AAGAAAATTG TTTTTCCTTC TTATTGGATT 13200

13201 TATGAACTAA GCAGCTGTAA ATTGCATTCA GCATCTTATT TAATCCACAT GAATTCAGTT AACATATATT TATTCAGTGC 13280

13281 TGGTCACTGT AGGTGATAGA AAAGTGTTAT GAACCATTTC CTCAAACTCT TCACAGAACT ATAAGAACTG GCATTAAAAA 13360

13361 GGACTAGCAA ATGTGGTAGG CCTTGGTGGA CATAGTTCAT TTATCAGGAG AGATCTTTGA GGGCTAAGGC ATTGGGTAAG 13440

13441 GTTTTGTGTA GGAAGTAGGA CTCATGGACA AGTAAAGGCT CTTAGGATGG TGAGCACTGG CACGGTGACA TCTGTGGTGT 13520

13521 AGGAGAAAAC ATTGGAACAG TGGTTTAGGT GACTAAGTCC ACAGAACAAG AACCAAGATC GGAAGCCAGG TGTTATTACT 13600

13601 CCAGTTTTAT GCTTTGCTTT AGCTGACTCT GCCTTTCGGT TGGTAAACAT GCCTTTACTG TTTCTTCTGA AAGTGTTTAA 13680

13681 CTTCATGTTG AAAAATTAGT TTTTCATCTG TAGCTTCTTT TCATTTCAGG CAATGATGAA GTAAAACGGG GTGTCCTGCT 13760

{N D E V K R G V L L

13761 GATGCTCTTT GGTGGCGTTC CAAAGACAAC AGGAGAAGGG ACCTCTCTTC GAGGGGACAT AAATGTTTGC ATTGTTGGTG 13840

M L F G G V P K T T G E G T S L R G D I N V C I V G

13841 ACCCAAGTAC AGCTAAGAGC CAATTTCTCA AGTAAGCGTT TGCCTGATAC AGTGTTGCAG GAAAAAGTGT ACATAGTTCC 13920

D P S T A K S Q F L K}

13921 CAGGCTGGCT GTGCTACCAA GAATGCAGTC AGTATGGCCT TACTAGGAGT GTAAATTATG ACTATGTTGA ATATATAATT 14000

14001 CTCATAGATT AAAGTTATGG CAACATTGTA CAATTTTTTA GAATAGGGAA AAATTGCCTG TAATACCAAT CTCACATTGA 14080

14081 ACTGTTTAGT CTTTGTATAA TATCTTTGTA AAATATATTT GTATAAAATT TTATACAAAT TTTATTATTT GTATAAAATT 14160

14161 TTATACAAAT TTTATTATTT GTATAAAATT TTATACAAAT TTTATTATTT GTATAAAAAT ATGAATTATG TATTTTCATT 14240

14241 ATTGTAAATC ATATTATACA TACTTGTAAT TTCAATTTTC TATAAACATT TTTTCCATGT TTCTTTTCGC ATGGAAAAAT 14320

14321 CTCATGAGTT TGTCATTTTC ACAATTGTCT TTTTTTGTTG GTATACTATA GCTTACAAAA TCATTTTCTT AGCCCTGTTA 14400

Exon 9

15841 TTTTTCTACA TCTGTTTAGG TGGTCATGTA GTTCTTTTAT TAATTTAGCA TATTGATTGA TTTTCAGATG TTAAACCAAT 15920

15921 CTTGCATTTC TGGAATAAGC CCCATATCTA GTTTTGTTTT GTTTTATTTT TAATTGCAAG ACCTTCTGAT AGATGATTGT 16000

16001 TGCTGTTTAT TACTATTAAA GACTTCTTTT AAAATTGATG TTTTAGCTGG GCGCGGTGGC TCACGCCTGT AATCCCAGCA 16080

16081 CTTTGGGAGG CTGAGGTGGG TGGATCATGA GGTCAGGAGA TCGAGACCGT CCTGGCTAAC ACAGTGAAAC CCCATCTCTA 16160

16161 CTAAAAATAC AAAAAAAATT AGCCGGGTGT GGTGGCGAGC GCCTGTAGTC CCAGCTACTC GAGAGGCTGA AGCAGGAGAA 16240

16241 TGGCATGAAC CCAGTAGGCA GAGCTTGGAG TGAGCCAAGA TCAAGCCACT GCACTCCAGC CTGGGTGACA GAGCAAGACT 16320

16321 CTGTCTAAAT AAATAAATTA ATTAAATTAA AAAATAAATA AAATTGATGT TTTAGGCTAG GTGTGGTGGC TCACGCCTGT 16400

16401 AATCCCAGCA CTTTGGGAGG CCAAAGTAGG TGGATCACCT GAGGTCAGGA GTTCGAGACC AGCCTGGCCA ACATGGTGAA 16480

16481 ACCCCATCTC TACTAAAAAT ACAAAAATTA GCCGGGCATA GTGGCGCACA CCTGTAATCC CAGCAACTCG GGAGGCTGAG 16560

16561 GCAGGAGAAT CGCTTGAACC CATGTGGCAA AGGTTGCTGT GAGCTGAGAT CACACCACTG TACTCCAGCC TGGGCGACAG 16640

16641 AGCAAGACTG TGTCTCAATT AAAAAAAATT GATATTTTTA TCAGGTATTA ACTCTGAAAA TACAAAAATT AGCCAGGCGT 16720

16721 GATGGCCCAC ACCTGTAATC CTAGCTACTC GGGAGGCTGA GGCACGAGAA TCGCCTGAAC CTAGGAGGTG GAGGTTGCAG 16800

16801 TGAGCTGAGA TTGTGACACT GCACTCCAGT CTGGTGACAG AGCGAGACCC TCTCAAAAAA AAAAAAGAAA AGCCGAGGGA 16880

16881 GAGAAACCTT CCCATTTAGT CTGTGGCATG TGTCTTCATG AATTGCTTAA GCTCTCAAAT GTTCTTTCAG TAATTTAAAC 16960

16961 TCTTCTGCTG GTTTTCCTGG GAAGGGTGCT GTATAATCAC ATATTAATGA GTCTTTATGT GATAACCTTG AACAGGCACG 17040

17041 TGGAGGAGTT CAGCCCCAGA GCTGTCTACA CCAGTGGTAA AGCGTCCAGT GCTGCTGGCT TAACAGCAGC TGTTGTGAGA 17120

V E E F S P R A V Y T S G K A S S A A G L T A A V V R

17121 GATGAAGAAT CTCATGAGTT TGTCATTGAG GCTGGAGCTT TGATGTTGGC TGATAATGTA AGAACATTTT ACACTCTTCA 17200

D E E S H E F V I E A G A L M L A D N}

Exon 10

17201 GTATAAAGAA GTCAGAATAC CCCTACCCTA TCAGTAAAGG CCTATAAGTT ACCATTAAAA AGATGTCCTT AAAAACAGCA 17280

17281 TTCTCAGCTG GGCGCGGTGG CTCACACCTT TGTCCCAGTA CTTTGGGAAG CCGAGGTGGG TGGATCACCT GAGGTCAGGA 17360

17361 GTTCGAGACC AGCCTGGCCA ACATGGCGAA AACCCATTTT CTCTACTAAA AATACAAAAA TTAGCCGGGC ATGGTGGCGG 17440

17441 GTGCTTGTGG TCCCAGCTAC TCAAGAGGCT GAGGTGGGAG GATCACTGAG CCCAGGAGGT GGAGGCTGCA TTGAGCCAAG 17520

17521 ATTGTGCCAC TGCACTCCAG CCTGGGTGAC AGAGCGAGAC TCTGTCTCAA AAAAACCAAA ACAAAAAAAA CCCAGCATTC 17600

17601 TTTAGTAAAT AATTCATAGT TTTCTTCATC TAGAATTTAA AATTGTGATA GTTGATCAGC ATGTCCTGAG CACGTGTGTT 17680

17681 TGCTGTTACT AGTTTAGATC GGTAGATGTG TATATAAGTT ATAGGTATAA AATCAATCCT GAGTTGACAC AAGGTTTTGA 17760

17761 TGTTGAGTAC AAGTACAGTA AGTGTATATT TTTAGTTATG CTCTTAGTTT TAAGTCAATT GTGTGGTTCT TTCTAGCTTT 17840

17841 AGGATCTGTT GAATTATCTT CCTTAGAAAA GGGAGTTAAG AATCTTCACT TACCTATCTT CTACTTGTTT GGAGAATAGA 17920

17921 AGAGTCCCTG TGGTAGCAGA CTTTGTGAGT TTACTTGTAA TTTTCCATCT GAAAGACTGT TCTTGTTTTT CGTGATGAAG 18000

18001 TCTTGCTCTG TCGCCCAGGC TGGAGTGCAG TGGTGCAACC TTGGCTCACT GCAACCTCTG CCTCCCGGGT TCAAGCAATT 18080

18081 CTCCTGCCTC AGCCTCCCGA GTATCTGGGA TTACAGGTGC ACACCACCAC ACCTGGCTAA TTTTTGTATT TTCAGTAGAG 18160

18161 ACGGGGTTTC ACCATGTTGG CCAGGCTGGT CTCGAACTCT TGACCTCATG ATCAGCCCAC CTCAGCCTTC CAAAGTGCTG 18240

18241 GGATTACAGG TGTGAGCCCC CACACTCGGC CGTTGTTGTT TTTTAAGAGA CAGGGTCTCA CTCTGTCACC TAACCTGGAG 18320

18321 TACAGTGGCA ATCATGGCTC ACTGTAACCT CAAATGCCCG GCCTTAGTGA AGCGTTCTTC CTGCCTTGGC CTCCCAAAGT 18400

18401 GCTGGGATTA CAAGTGTGAG CCATGCATCC AGCTTGAAAG ACAGCTTCTT AGGCTTGATT TGTTTGGTTA CAGGGTGTGT 18480

{G V

18481 GTTGTATTGA TGAATTTGAT AAGATGGACG TGCGGGATCA AGTTGCTATT CATGAAGCTA TGGAACAGCA GACCATATCC 18560

C C I D E F D K M D V R D Q V A I H E A M E Q Q T I S

18561 ATCACTAAAG CAGGAGTGAA GGTATGTGTT ATCTACTTCT GTTCTGCTGC ATCGTCCATA GCCTTGTTGA TTAATGTAGT 18640

I T K A G V K }

18641 ACTAGAGAAG TTCACCTGGA TAAAATTCAT TACTTCAGTG TGTAATGCTG TTCATTAAAA TGGAAAATAC AGCCCTGAGA 18720

Exon 11

18721 ATTATTTATT GAAACTATAA ATGTTGTTTA GAGTACTGTG TAAATGTATT GCCATGATAA TAGAGGAAAA TGTCCATGAA 18800

18801 CAAAGCTTTT ATTTTCTTTG ATAAAGCATG CTCCAATTAT AACAAAAATA ACCAAAGATC AACAGATTGA TTATATATGT 18880

18881 ATATATTTAT TTATATTAAC AGAGTATTTA AATGAAAATA AGTATGACAG TATAACCAAC ACTAGGGAGA ATCTAAACTT 18960

18961 TAAAAGCTAC AGATTCAAGT AGCTTTTAAG CAGTACACAA TTGTAAATTG AAAAGACAAC TCTTTCCCTG CAACTCCCAG 19040

19041 CAACAGTAGA TACTTAGAGG TATCTAATGG ATAAAAAGGA ATTTTAGGAG GAGGAAAATA AGGCATCTAT TGAGTTTGTG 19120

19121 CCCCTTTTAG GAATATTTTG TACATAAGCA TAATACTGAC AATTTCATTC CTGCTGGTTT AACTTCATAA TTTTATTTTG 19200

19201 GCAATCTTTT ACCAGCACAT ATTAGATCAA CTTTGGTTTT TTATTAATTT CCCATATTCA ATTGTGTATA CCACAGCTTG 19280

19281 ATTCTTTAGA CTCCTGTTGA GTGACATTTG GTTCATTTTC AGTGTTTTGT ATTACAAACA AAATTGTAGT AAGCATCCTT 19360

19361 GAACGCAACA TCCTTTTATA TTTGGCTATA AGAGAAATTT CTAACAAATT GATGTCTTCA ATGGTGTGCA CATCATACCA 19440

19441 CCAAAATCAC ATAGGAGTTC CTGTTTATGT GAAAAAGGGT ATGTCATTAT TTTGGTTTGT GTTTAGTTAA TTATGGGTGA 19520

19521 GATTGAACAT GTTGTTATAT ATTTATTGGC TGATGTCTAT TTAAATCTGT TAAGATTCTT TCTTTTGTGG TCAGGCTACT 19600

{A T

19601 CTGAACGCCC GGACGTCCAT TTTGGCAGCA GCAAACCCAA TCAGTGGACA CTATGACAGA TCAAAATCAT TGAAACAGAA 19680

L N A R T S I L A A A N P I S G H Y D R S K S L K Q N

19681 TATAAATTTG TCAGCTCCCA TCATGTCCCG ATTCGATCTC TTCTTTATCC TTGTGGATGA ATGTAATGAG GTAACCCCAT 19760

I N L S A P I M S R F D L F F I L V D E C N E V T}

19761 GAGCTTCCTT TTTTATTTCC AGTTGGAGTA ATCGAGTGAG ACAAGGCTGG AAGATACACT GCTCAACAGC TGGTGCATGT 19840

19841 ATGTGCACCA GCCTTTGATT TCCCTCAGGG TGGCACAGGA TCGGACAAAG GGTTTAGTAA GCAACTCAAA ATAAAGTCAT 19920

19921 TTGAATTGCC TCTTCCACTT AATTGTGTTC AAGAATTAAG TTTTCAGGTT TTGTTACTAT TTATTTCTCA AAAGGAAACA 20000

20001 AGTTACAGTT AACTTCCAAC CACACTTTTT ATTTTTTTAA ACAGCCTCTC ACTGGAGACT GGGCTGGAGT GCAGTGGCAC 20080

20081 AGTCTTGGCC TACTGCAACC TCCACTTCCA AGGTTCAAGC GATTCTTGAG TCTGAGCCTC CCAAGTAGCT GGGATTACAG 20160

Exon 12

23041 AGGCTTACTC TGTTGCCCAG GCTGGAGTGC AGTGGTGCAA TCATGGCTTC ACTGCCCCTT CAACCTCCTG GGCTCAAGTG 23120

23121 ATCCTCCTGC CTCAGCCACC TGAGTAGCTG GGATTACACA TGTGCACCAC CATGCCCAGC TAGTTTTTTT GTAGAGACAG 23200

23201 GGAGGGTCTC AGTTTGTCGC CCTGACTGGT CTCAAACTCT TGACCTCAAG CTCTTCTCTC ACATCAGTCT CCCAAAGTGT 23280

23281 TGGGATTACA AGTGTGAGCC ACTGCACTTT ACCCTACTAT TGTTTTTAAA GCCAATCAAT TCCTTCAGGT ATAGTTTTAG 23360

23361 AGTGGGGCAA TGGTATACAT TTAAACGTTT GATTTTAAAT CCACCTGTTC CCAAACTTTC ATCAGAAACT TGGTACCCAT 23440

23441 TAATACTTCT TTAAGTGGTA TATTAGAGCT TGTTTTTGGC GATAAATCAT TTCTTATTGC CTGGGATAGT CTGGAGAAGA 23520

23521 TATTGCTGTG ACTATCAAAG TGATTTTTTT GTTTTGAATT AGGTTACAGA TTATGCCATT GCCAGGCGCA TAGTAGATTT 23600

{D Y A I A R R I V D L

23601 GCATTCAAGA ATTGAGGAAT CAATTGATCG TGTCTATTCC CTCGATGATA TCAGAAGATA TCTTCTCTTT GCAAGACAGT 23680

H S R I E E S I D R V Y S L D D I R R Y L L F A R Q

23681 TTAAACCCAA GGTAACCTAC CCTTTTGTAC TGGGATAAGG TATAATGGGT ATATTAAAGT GGAATTTAAG TAAGTGTGTT 23760

F K P K }

23761 ATATGGAAAT TAACTGAACC TGTCATCTAC CTTAGTTCCT AAATTTTACA ACTTTTTTTT TTTTTCTGGA ACAGCAATTT 23840

23841 GTTTTTTCAG AGAGGGCTGA GAAAGGGAAC TGTAAAAAAA ATTCTGAATA ATTCCATTAT TTGTTTGGTG GTAATAAAAA 23920

23921 GATTTGTATG GGAGAAGAGT TTTGGATAAC TGGATAATCT AGAACATTCT TTTATTTCAA ACATTACTAA GAACGTTAAA 24000

24001 ATTGTTTATG CGCCTAAATC AATAGTTGAA TCTTTCTTTG AAGGAAACAT TGGATTCATC TAGGCCATTA TGATAAATAT 24080

24081 AAATTACTGT TTTACAGTGA TTGATGCATT GTATTGGACT AACTCTGTTC TGGACCCAGG ATTCTTACCT GGACATAAAC 24160

24161 CCCCAAATGC TTGGCATTTT CCCAAAATAG GGTATGAAAA GGAAAAAAAA TACTCATTCT GGTTGAGATT TTCACACTGT 24240

24241 TGGCTAACTT GACTTCTGGA AGGTGTTACT AGGTATTGAT CATTTATCAT CTTCACTTGA TTATTCATGA GATTGCAGTT 24320

24321 GGCTCTCACT GTCCCAAAGA AATTTAATCA TTTAAAACTA AGGATTATGG GTGATTCTTG TGTAAAAAAG AGCATCTGTT 24400

24401 CTCCATTACT GCATACTGAT ATACTGATCC CTCTGTAACC TTGGCATGCT TCCTTAATAT GGTGAATTCC TTGCTCTGAA 24480

Exon 13

24481 AAGCTGAGGA TCCTTTAGAT ATAAAGTTTA TTGAAACAGC TTTTTTTTCC CTGCAAAGAG TGTGAGTTAA TTAATTGAGC 24560

24561 CTCAAATACT GAGCATTAAT TTATTTAATG AGCACTGACA TCCTGAGGTG TAAAAGACAT TACATCTTGT TCCATTGCTT 24640

24641 CAGCTTGTTA AGCAGCTTTT AGAAATGGTC ATTTGCTTAA ATACTAAGCC TTTTTTCAGG TTCATAAAAT TAGTAACATG 24720

24721 GAATTCACAA GCCTCCTTAA TATTAGTTTC TTTTGAAAGA CATTACAATA GTAATTTATT GTCACTGGCT TCTCAAAGTT 24800

24801 TCAACCCTCT CAGGTTCCCT AAATGTTTCC ACCTGGAAGG CTCTTAAACT TAGGTTTACC GTAGCTCTCA TCAAATAGAA 24880

24881 ATGTTTCTCT AACTTGAGTG ATGATCTGAA ACAGATTTCC AAAGAGTCAG AGGACTTCAT TGTGGAGCAA TATAAACATC 24960

{I S K E S E D F I V E Q Y K H

24961 TCCGCCAGAG AGATGGTTCT GGAGTGACCA AGTCTTCATG GAGGATTACA GTGCGACAGC TTGAGAGCAT GATTCGTCTC 25040

L R Q R D G S G V T K S S W R I T V R Q L E S M I R L

25041 TCTGAAGCTA TGGCTCGGAT GCACTGCTGT GATGAGGTAT CAGAGTCACT TTGATATGAT GAGAGCAGAG ATAAACAGAT 25120

S E A M A R M H C C D E V}

25121 TTGTTGCATG TTTTTAATCT TTGGTATGGG ACATACTAGA ATTCACTGCA AATACATTTT TATGTAACTG TTGAATGCTC 25200

25201 ATACGACCAT GGAATTCTTC CCTTTAAAGA GCTTGGTAAG CATTTGAGTG TAGTTGTTAG ACGGAGACGA TCACGTCATA 25280

25281 GTTTATAGAG TGCATAAAGA CGTAAGTTAC CATTTAATAC CTTTCATTCA GGAAAAATGT ACTTAGACCC TACAATGTAC 25360

25361 TAGTAGGCCT CTGCGCTGGC AATACAGATA AGATAATGTA GCCCCTGGCC TCAAAGGAAC TCTCCTCCTT AGGTTGCATT 25440

25441 TGTATAATGT TTGATTTTTA GATTGTTCTT TGAGCCCTGC ATTCCACGAG GATAGGTCAG TGGGTATTAA CGAGGTAAAA 25520

25521 GGGGAGTAGT ACGAAAGGGC ATTCAAGCGT CCCATCTTCG CTTCAACCAA AGCAGCCCTG CGTTTTCCTA GTTTTATTAA 25600

25601 TAGGTTTGAT GTAAGGTCGT CTTTGAAAAG GGGGTTTGGC TTTTTTTTAC AGTGTGACTG AGGTATAATT TATAAAAAGG 25680

25681 GAAATGTATG GCATGGTGAG TTTTTTCACA TACATCCTTG TGAATACCCA GCTCAAGATC CAAAACATTT CCATAATTTC 25760

25761 AGAAAGTTCC AAACCCCTGC CTCTTTTCAG TCTTAGCCCT CTTCCCCTGA AGTAACCACT GTTCCGACTT CAATCACTAC 25840

25841 TTTTATCCCA CAGGTTAATT TTTTGGCTTT TTTCCACTAA ATTTTCAAAT TCTTTGATAT GGTACTTTAC TATTGACGAA 25920

Exon 14

27361 GAAGAGCAAA CATTTGTGAA CAGTTCTGAG TACCACAAAT ACCGTTATCT TTCCACTTAA GTCTTCTGTT TCACTCAGTA 27440

27441 GTGCTTTAAA CTTTTCTTCA TATGTTTTTC AGTGTTTCTT GTTGAATTTC TTGATATTTT ATCATGTTTG TTCGTACTGG 27520

27521 GAGTAGCCTT TTTTTCCATT TCATTTTCTG GCTGGTTTCA TTGCTGGTTG TTTTTTTGTT TTGTTTTGTT TTTGAGATGG 27600

27601 AGTCTCACTC TGTCGCCCAG GCTGGAGTGC AGTGTCACAA TCTCGGCTCA CTGCAACCTC TGCCTCCCAG GTTCAAGCGA 27680

27681 TTCTTCTTTC TCAGCCTCCT GAGTAGCTGG GATTACAGGC ATGTGCCACC ATGCCCAGCT AATTTTTTAT ATTTTTAGTA 27760

27761 GAGATGGGGT TTCTCCATGT TGGTCAGGCT GGTCTCAAAC TCCCAATCTC AGGTGATCCG CCTGCCTCTG CCTTCCAAAG 27840

27841 TGCTGGGATT ATAGACATGA GCCACCGTGC CTGGCCTAGT TCTTATGGGA TGTATATGTC TTTGGATTCA TATGATATGT 27920

27921 ATATATGTTT ATATTTCTAC AAGTACATAC CTAGGAGTGG AATTGTTGGG TCATAGGTTA ATGCATGTTT TTCTGCCAAA 28000

28001 CAGTTGTGTC AATTTCTGTT TTCACCGCTG TGAATGAGAG TTGTTCTACC TTCTTGACAA CACTTGATAT TGTCAGTCAT 28080

28081 TTTAGCCATT CTGGTGAATT TATAGTGCTA TTTCTGTGTG TGTAAGAGAG AGAATGAGAG AGGGTGTTTG TGAGAAAACC 28160

28161 AAAGCAACAC TGTGAGAGTG TGTGTGTTTG TGAGAAAACC AAAATACATA CTACTGTGAT TTCATTGGGA GAAAATCTGT 28240

28241 TTGGTATATC AAAAAAAGTA GCTTAATTAC TTCATCATTA TTGGTTTAGG TCCAACCTAA ACATGTGAAG GAAGCTTTCC 28320

{Q P K H V K E A F

28321 GGTTACTGAA TAAATCAATC ATCCGTGTGG AAACACCTGA TGTCAATCTA GATCAAGAGG AAGAGATCCA GATGGAGGTA 28400

R L L N K S I I R V E T P D V N L D Q E E E I Q M E V

28401 GATGAGGGTG CTGGTGGCAT CAATGGTGAG ATACTTGTTC ATGTGACTGT TTTGGAGTTA GGGACCAAAA CATTTTCTGA 28480

D E G A G G I N G}

28481 GATGTCATGT GGTAGAAGTA CACCTGCTGT TGGCTAATAG TCTATGGTAG CAAAACGGAA AAAGCAGATA CTGAATTCTA 28560

28561 TTCACTGTTT ACAAGTTAAA ATGAAATTAA ATAGTTGATA TAAAATATAT ATACTTGGCT GGGCACGGTG GCTCTCGCCT 28640

28641 ATAATTCCAG CACTTTGGGA GGCTGAGATA GGTGGATCAC AAGGTCAGGA GTTTGAGACC ACCCTGGCCA ATATGGTGAA 28720

28721 ACCCCTTCTC TACTAAAAAT GCAAAAATTA GCCAGGCGTG GTGGCGGCTG CCTGTAGCCC CAGCTACCTG GGAGGCTGAG 28800

Exon 15

28801 GCAGGAGAAT CACTTGAACC CGGGAGGCGG AGGTTGCAGT GAGCTGAGAT TGTGCCACTG CACTCCAGCC TGGGTGACAG 28880

28881 AGCGAGACTC TGTCTCAAAA AATACATAGA TATTTGAAAG ACTAAAAGAA AAGGCAGCAA AATGGTGATA ATAGACATAA 28960

28961 ATCCCCTGGG TTTTACCCTT ATTTGTATTG TTGTTTTGCT TCTGAATTGA AAACATTTTT TCAAGCACAT TAGAACAGAA 29040

29041 AAATACTAGA AATTTTATTT ATTTTGAGAT GGGGTCTCAT TCTGTCACCC AGGCTTGAAT GCCTTGGTAC ACTCATGGCA 29120

29121 CTGCAGCCTT AACTTCCTGG GCTCAAGCAG TCCTTCTCCC TATCCTCTCT AATAGCTGGG ACATATGCCC ACGCCACCAC 29200

29201 TCCTGGCTAA TTTTTTGAGA ATTTTTTCTA GAGACAGGAT CTCGCCATAT TGCCCAGACT GGTAGAATTT TTTATTTTGT 29280

29281 ATATAATACT GCAAGTGGAC TTTCAGATTG TGAAATCTTT ATATCTCTGA TCCCTCACGT TCCTCCCAAG TTAGTTTTTG 29360

29361 TCTTTACTAG TAGAGTTTAT ACATTTGCTT CTAATTTATT TGAAAATTCT TATATGCTAT GTATAACTGT ATGCATGTTT 29440

29441 TTTTTTGTTT GTTTTTTGTT TTTTTTTATT TTTGAGATGG AGTTTTGCTT TTGTTGCCCA GGCTGGAGTA CAATGGTGCA 29520

29521 ATCTCATCTC ACTGCAACCT TTGCCTCCCG GGTTCAAGCA ATTCTCCTGC CTCAGGCTTC CGAGTAGCTG GGATTACAGG 29600

29601 CACCCACCAC CACACCCAGC TAATTTTTGT ATTTTTAGTA TAGACAGGAT TTCACCATGT TGGCCAGGCT GGTCTCAAAC 29680

29681 TCCTGACCTC AGGTGATGTG CTTCCCTTGG CCTTGCAAAG TGCTGGGATT ACAGGTGTGA GCCACTGCAC CTAGCCGGTT 29760

29761 TATTTTGTTT TTCATTTTTA TTTTTTGGCA GAGGAGATCA TGTGGGAATG TATGCTTGTT TTAAAATTAG TGTTAAGGCT 29840

29841 GGATGTGGTG GCCCACACCT GTAATCCCAG CACTTGGGAG ACCAAGACAG GAGGATCAGT TGAGTCCGGT AGTTCGAGAC 29920

29921 CAGCCTGGGC AGCATAGCAA GACCCTGTCT CTAAAACAAA TAATAATAAT AATTTTTAAA AGTGAAAAAA ATCAGTATTA 30000

30001 AATGTAAGTA GTGTATTTGT AAATGCTTGA CAAGGGGATG TTAAGGGCAC AAAAATAAGA TTCAGGTGGT CAATTTTTCA 30080

30081 CTTAGGTCAT GCTGACAGCC CTGCTCCTGT GAACGGGATC AATGGCTACA ATGAAGACAT AAATCAAGAG TCTGCTCCCA 30160

{H A D S P A P V N G I N G Y N E D I N Q E S A P

30161 AAGCCTCCTT AAGGCTGGGC TTCTCTGAGT ACTGCCGAAT CTCTAACCTT ATTGTGCTTC ACCTCAGAAA GGTGGAAGAA 30240

K A S L R L G F S E Y C R I S N L I V L H L R K V E E}

Exon 16

31681 GGCTTGACAT TTATCTAATC TGTACATTAT CTCGTTGTAT ATGTGGCAGA GATTTACCCA AGGACTGACA GTACGAGTTG 31760

31761 CTAGGATAAT TTGAATGTGT TTTTTTGTTG CAGAAGAGGA CGAGTCAGCA TTAAAGAGGA GCGAGCTTGT TAACTGGTAC 31840

{E E D E S A L K R S E L V N W Y

31841 TTGAAGGAAA TCGAATCAGA GATAGACTCT GAAGAAGAAC TTATAAATAA AAAAAGAATC ATAGAGAAAG TTATTCATCG 31920

L K E I E S E I D S E E E L I N K K R I I E K V I H R

31921 ACTCACACAC TATGTAGGTG CAGAAGTGCG CGTGCTCTGG TATCAGGGAG GGAGGGAGTT CATGCCCTGT ATCTGCAGGT 32000

L T H Y}

32001 TCACTAGTGA AATTTTTTTT GACCTTTGTT TGTTTTGAAT CATTGGAGTG TAGTCAGAAG TATGAGTTGT AAAATAAGAG 32080

32081 AGAATGAACA GCAGGTAAAT GACTTATTTC CTCTGCTGAA ACAAGCAGAA TTTAGGTTAA ATCTCAGAAG GTGGGATTGA 32160

32161 AGTCTTACTA GTTAGGTGTT TTAAGCTTCT GTTTCCCATC CTCATATTTG CCCTTGGTCG TACTGCTGTC ACCTACTTTC 32240

32241 TATGTTTCAT TTTCCTCACA TTCTTAGTTC CCACCTTACC CAACCCAATA GTCAATCTTC CATCTTACTT GCTTGGCGAA 32320

32321 ACCCCAAACT TGGTTAAATA TAACTTTTTT TTTTTTTTGT ATCCTTATCT AAGCAGCTGA AAGTATCTGG AGAAAAGCAT 32400

32401 ATAATTATGA GCCCAGTCTT ATTTAAATCG ATGACCAGAA ATCTCAAGTG GACAGTTCTT ACTGTCTCAT CAACCTCATG 32480

32481 ACAGCACTGC CCAGTGCAAT TCCTTTTCCC GGGTCAGTTC TTTGCCTCAC TCTCTCACAG GCCCATCACA TACCTTCTCT 32560

32561 CCACTCCTGT CAGCTGGCCA TTCTCAGTAC TCAGCCTGTC CACAGCTTTG TCACAGTTGA TCACTCCTAC AAATAGTGTC 32640

32641 TTCCTCACTT GGTTCTGAGT CACTGTATCC TCCTGGGGCT TCTTTCTCAC TGGTTATTCC CTCTTAGTCT CTTTCCCTGA 32720

32721 ATGGTTTTGT TTTTTTTTTT TTTTTTTGAG ACAGAGTTTC GCTCTTGTTG CCCATGCTGG AGTGCAGTGG CATAGCTCAC 32800

32801 TGCAGCTTCC ACCTCCTGGG TTCAAGCGAT TCTCCTGTCT CAGCCTCCCA AGTAGGATTA CAGGCGCCGG CCACCACGCC 32880

32881 CGGCTAATTT TTTAATTTTT TTTTTTTAGT AGAGATGGGG TTTTGCCATG TTGGCCAGGC TGATCTAGAA CTCCTAACCT 32960

32961 CAGGCGATAC GCTCACTTTG GCCTCCCAAA CTGCTGGGAT TACAGGCGTG AGCCACCGTG CCTGGCCTGA ATCTTTCTCT 33040

33041 TCTTACTTTA CTCTCAGATA GTTTACATTC ATTACCTAAG TGATCTCATT TGGTTTTATG AATTTATCCA TCTACTGATG 33120

Exon 17

34561 GGCCAGGCTG GTCTCAAACT CCTGACCTCA GGTGATCCAC CCACCTCAGC CTCCCAAAGT GCTGGGATTA CAGGCATGAG 34640

34641 CTACTGCGCT CAGCCTGGAT TACCTTTTAA AATTTGGCTT ACCACCTGAA CTAATTTGCT ACAGAAAACT AGAGAGCTTA 34720

34721 TACTGTGCTG ATGAGATATG ATGCTTCCTA TGAAGGTATG TTAACACATA GAGTGAGTGC TTGAAAGTGT CCAATCTAAC 34800

34801 TTCAGGGGTA GATTTGAAAG GGCAATTTTT TAAAAAGTGT CCAGTCCCCC TTAGTGGCTT CAGTGTTTAT ACTGTGGAGC 34880

34881 CTTGCCAGAC TTCTTAGGAT CAAATCACAG TTTCCTGAGT TCCTTTCTAT GGGCTTGGCT AGGAGCTCTT CTCATTTGTG 34960

34961 GACAGTTTTG ACTAACCTGT AATTATATCG TGGGCTTAAA ATCTGTCATC AAGATTTTAA GCCAGATGGC ATGTTCTACC 35040

35041 TTTTTTTTTA TTAGCTCAGA GTGAAAAATT TTTCAGATGA ATTTTCATAG ATTCTTCTCC TAACTCTATG AAATGGTGGT 35120

35121 ATATGAAAAA GTTCAGTGGT CATAATTAAA AATTGCTGAA TGATATTAAG TATGAAACAG ACTTCCAATT AATTAGAAGA 35200

35201 TTTTGCAGAG TTGTTTAACC TTAAAATTCA AGCATTACTT CCTTTTTTGA AGTTGTATTT ACAAGCATTT GATGTAATAT 35280

35281 ATTTAAGTAT TTCTTAATTT TCCACAAGGG GTTTATGGTA TGAAAAGGTC AGCATCCTAC TAGGAACAGG GTTTAGCAGA 35360

35361 GCACTGATAG TGATTTTTAA AGTGTGGTCC TTTTCCTAGG AGTTTCTAGT TGGGAAATGA AAGAAAATGT TGATAGCAAA 35440

35441 CACTCGGAAG AAGGGTCAAG TCTTGTATAT CTGGACATTG GTATAATACT GCTTGAAACC TGAGGACAAA TATTTGTGTT 35520

35521 TCACAGGATC ATGTTCTAAT TGAGCTCACC CAGGCTGGAT TGAAAGGCTC CACAGAGGGA AGTGAGAGCT ATGAAGAAGA 35600

{D H V L I E L T Q A G L K G S T E G S E S Y E E D

35601 TCCCTACTTG GTAGTTAACC CTAACTACTT GCTCGAAGAT TGAGATAGTG AAAGTAACTG ACCAGAGCTG AGGAACTGTG 35680

P Y L V V N P N Y L L E D}

35681 GCACAGCACC TCGTGGCCTG GAGCCTGGCT GGAGCTCTGC TAGGGACAGA AGTGTTTCTG GAAGTGATGC TTCCAGGATT 35760

35761 TGTTTTCAGA AACAAGAATT GAGTTGATGG TCCTATGTGT CACATTCATC ACAGGTTTCA TACCAACACA GGCTTCAGCA 35840

35841 CTTCCTTTGG TGTGTTTCCT GTCCCAGTGA AGTTGGAACC AAATAATGTG TAGTCTCTAT AACCAATACC TTTGTTTTCA 35920

35921 TGTGTAAGAA AAGGCCCATT ACTTTTAAGG TATGTGCTGT CCTATTGAGC AAATAACTTT TTTTCAATTG CCAGCTACTG 36000