PIKACHURIN
Isoform 4
AGRINL and EGF-like, fibronectin type-III and laminin G-like
domain-containing protein (EGFLAM)
FUNCTION
● aids in normal formation of the ribbon synapse
● transmit visual data from retina to the brain
through the CNS
● speeds up transmissions
Without it:
● slowed down transmission
● vision affected
● can lead to a muscle-eye-brain disease
○ congenital muscular dystrophy
on
CHROMOSOME 5
DNA + AMINO ACID SEQUENCE (PROTEIN)
Exon 1 (192935:114): MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVF
Exon 2 (199901:87) : SYNLGSGVASIMVNGSFNDGRWHRVKAVR
Exon 3 (204501:105) : DGQSGKITVDDYGARTGKSPGMMRQLNINGALYVG
Exon 4 (205426:150) : GMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK
192651 UGGCCAUAGU CUUGCUAAUC UGUCACUCAG CAAAUGCUCU CUGGUGGGGU 192700
192701 UCACAGUGCU UGGGGAGAGA GACUGCUGCU GAGUGAGCAG UCCAGACCUU 192750
192751 UAGACCCGUG GUGCGACUCG UGGUAAUGAA GUAAGUGUCA GAAAGUGCCA 192800
192801 GACUAUCCUU ACAUCUGGUU CCUCAGGGCU GGCAGACAAA ACUGGAAUUA 192850
192851 CUCGGAAACA GAUGUUGGUG GUUGAUUUGG UGGACUUAUU UGUGUAUUUC 192900
192901 CUCCAGGGUG UCAGGAUCAA GAUCAAAUGU GUUCAUGAGG UUUAAAACAA 192950
{M R F K T
192951 CUGCCAAGGA UGGCCUUUUG CUGUGGAGGG GAGACAGCCC CAUGAGACCC 193000
T A K D G L L L W R G D S P M R P
193001 AACAGCGACU UCAUUUCCUU GGGCCUUCGG GAUGGAGCCC UCGUGUUCAG 193050
N S D F I S L G L R D G A L V F}
193051 GUAACCCCCU CUCCAUCUGC CUUCAGCAGC ACCUUGCGAU UUUCUCAGAC 193100
193101 AUUGCAGAUC AUGCCAGAGU GAUUCAGAAG GGAGCCAGAA CACAGUCUGC 193150
193151 UGGAAUUGGC UGAAGCCUGA AGCUUCAAGG CUUAUUGGAA GCUCCUGGUC 193200
193201 UUUCUUUCCA ACAUUCAUCU UAUAGAGCAG CAGUCAGCAA ACUAUGGCCU 193250
193251 GCAGGCCAAA UCUGACCCAC CACUCUUUUU UGUAAAUAAA GUCUUGCUGG 193300
193301 GGCCGGGCAC AGUGGCUCAC GCCUGUAAUC CUAGCACUUC GGGAGGCCGA 193350
193351 GGUGGGCAGA UCAUUUAAGA UCAGGAGUUU GAGACCAGCC UGAGCAACAU 193400
193401 GGAGAAACCC CAUCUCUACU AAAAAAUACA AAAAUUAGCC GGGUGUGGUG 193450
193451 GCAGGCACCU GUAAUCCCAG CUACUAGGGA GGCUGAGGCA GGAAAAUGGC 193500
193501 UUGAACCCAU GAGGCAGAUG UUGCAGUGAG CUGAGAUCGC GCUACUGCAC 193550
193551 UCCAGCCUGG GUGACAGAGC AAGACUCCAU CUCAAAAAAA AAAAAAAAAA 193600
193601 AAAGAGUACA GCAGUAUUCC AACAGGACUU UUUUUUUUUU UUUUUGAGAC 193650
193651 AGGGUCUUGC UGUUGUCGCC CAGGCCAGAG UGCAGUGGCG CAAUCUCGGC 193700
193701 UCACUGCAAC CUCUGCCUUC UGGGUUCAAG UGAUUCUCUU ACCUCUGCCU 193750
193751 CCCUAGUAGC UGGGAUUAUA GCACGUGCCA CCAUGUCUGG CUUUUUGUAU 193800
193801 UUUUUGUACA GACGGGGUUU CACCAUGUUG GCCAGGCUGG UCUCAAACCC 193850
193851 UGACCUCAGG UGAUCCACCC GCUUCGGCCU CCCAAAGUGC UGGGAUUACA 193900
193901 GGCAUGAAUC ACUGUGCCUG GCUUGUACUC UCUCAUUUAU AUAUUGCCUG 193950
193951 UGGCCAUGUU CAUGCUACAA UGGCACACUU GAGUAGCUUC AAUAGGAACU 194000
194001 GCAUGGCAGA GCCUUAGGAA UUGACCGUCU AGCCCUGUGA GGAACAAUUC 194050
194051 UGUGCCCUUG UUCUAGUGUG UUACUGCUGC AUGUUCCCUA CUCAUAAAUU 194100
194101 AGGAAGGGGC AGAAAGAAGA CUUGGAUACU GCCAAGCACA AAGGCCAAGC 194150
194151 AUAGAAGUGA GUACUCAGCC UAAGACUCAG CAGCUCAGGG AGGUCUAAAA 194200
194201 CCCUAAGCUC CAGGAGCCCU GACUUUAAAU UCUGACUCUG CUCCCUGUUA 194250
194251 GCUGUGUAGC UGUGGGAAGG AGAAUCCCUG CUUUCAAGUC UCCUGCUGCC 194300
194301 AGAGGAACAA AGCACAGAUU CAUGUCUCAA UAGAUCCACC CAACAUGAGA 194350
194351 GUUUUGUAAA UACUUCUUGG GUGUUACCGA UAACGCAGUG CCAGAAGUUC 194400
194401 UUCCCUCUUU UAAGUGAAUU UAGACUGUUU CCAAAUUUGU CAAAUGCAUA 194450
194451 GCUAUGAAGU GGUUAAAGAA UUACCUGAAU GAGUUCUCCC CACUCUUCUU 194500
194501 ACCAGAUUGG GUGAAAGCUG AGCUUCCAAG GGGCAGGGCC UGUCUCGUGU 194550
194551 AAUAUCAAAA CACUUCUCUA GAGAUUGUCA UGGCACAUCC UCACAUGAGG 194600
194601 UUAGACAUCG CUCAUCUAGA CAGUGGCUUU CCAAGUGUGG UCCCCAGACC 194650
194651 AGCAGCCCCA GCAUCACCUG GGAACUUGUU AGAAAUCCAC GUUCUCAGGC 194700
194701 CCCAACCUGA UCUACUGAAC CAGAAACACU CUAGGGGUGG GGUCCAGCAA 194750
194751 UCCGUGUGGU AACCGCUUCC CCAGACGAUU CUGAUACCCU CAAAGCUUUG 194800
194801 AGUUCCAUGG GGGAACUCAU UUCUUGGACU UCUACUUCUU AAUUCACCCU 194850
194851 CUGAUGACUA GCUCAAGUGU UUGCUAAAUG AUAUGAAAGU AAUUGAAUUG 194900
194901 AAAUAGACAA AGCAGGGAUC ACUAAACAGU GGAGAAGCUG AAGACUUAAU 194950
194951 UCUGGGGCUU CUGUUGGUCC UGUGCUAAGA UUACUGACAG CCCAAGUAGG 195000
195001 AUAACAGAAA UCUUUCUGUU UGAAUAAAAG GCAUUUUGAG AGGAAAUGUC 195050
195051 ACUUGUCCAA UGUUAUGCUA UUCCCUAAAU AGCAGAGCAU GCUAAGUGAC 195100
195101 UCCAUCUUAU GAUUGUUGGG GACUUUGGAG ACUCAUAUGU AGUUGAGGCU 195150
195151 GGAUGCUGGC AGGUGAGAGG CAGCUUCUCA CCAUCUCUGC CUUCCUGUCC 195200
195201 UCCGUAGCCU CCCACCCAUU GCUAGCCCAG AGGUUGAACA CGGAGCUCUU 195250
195251 CACACCCUAU UUCAGGCUGG CUGCCUUGAA GCCAUUUUCU UAUGGUUUUC 195300
195301 CUGUGGUUAA CCUCAUCAAG GCCUCAAGUA CUUGAUUGUG CCCAGAAAAG 195350
195351 AGAACCGAAA CAGAAGCUCA GCUGUGGGUG GGAUGGUCCA ACUUCCCCCU 195400
195401 AAACUGCCAG CUGAAUCUAU UCACCACCCA UUCUACUCCA GUAGGGAAAC 195450
195451 AGCUCCCACC AGCUCCCAUG CCCAGCCCUG GAGAGCCCCC UCCCCUCUCC 195500
195501 CACCUGCUUA GGAUCCUUCA AAGAGCUCUG CUUUAUCCUG AACAUACUUC 195550
195551 UUGUUACCAU UUCUUUCUCA GGAUUCUGAA AAUUGGCCCU CUGUUUUUCU 195600
195601 UCCAAUCCUG GAGUUCUGAU UGUGAUCUGU GUAAGACACA CUGCUGAACC 195650
195651 CAGGCCGAGG UCGACUUCUG UGCCUGCUCU GGUCCUGGAG CCGCCCCAUU 195700
195701 GCUGCCACUC UGUUCUUCCU CCAUCUGGGC UGUUAUCCCA CCACAUCAAU 195750
195751 GUCCCCGAUG CUGAUGUAGG GAAGCGUACC GGCGGGCUGG GGACAGAGAG 195800
195801 GAAUUCCAGU GUAGGCCAGU GGUUUGAAGA UGUCAGCGGU GUGGUGGGCA 195850
195851 CCGGGUCUGA UUAGAAACAA GCACCCGGGU GUUUCCGGGA CCCAUGCCCU 195900
195901 GAGAAACAGG GUCUGAAGUG GCUUUGGAAU CACACAUGCC UGAUCCCCCA 195950
195951 CGUGGGCUCA UGAGUUACCU AAAUCUCAGC CUCUGUCCCC UCCUUGCAAA 196000
196001 ACGACAGGGU UCGCUGUAAA GAUUAAAUGA AUGAAUUCAU GUAAGGGGUU 196050
196051 CAGUGUGGGG UCAGGUGUAG CUAAUUAAUG AUAAUGAUAA GAAAAAUUAU 196100
196101 GAUCCUUGCU CAAGCAUUUU CUGAGUCUUA GAAGCCUUUA CCUCAGAGAG 196150
196151 AGAACACGUA GUUAUUAUUA AAAUGUAGUU CUUAUUUUUA UUAUUGUUAU 196200
196201 UGUUAUUUUU AAUAAGUCAC GGGCCCUGCG CCCAAGGGGC ACAGAUCUGU 196250
196251 GCAGUCUGGA GAGUGAAUUG UUCUACAGAG CAGACAAAUC GUUCUUGAGG 196300
196301 UUUCAGUGUU UGAUCCAGGC UCAAAGCAGA UGGAAGAGGA ACCCUAAGAU 196350
196351 AAUAAAAUAU AGUCCCAACU UUCAUGACUU UCUUUACCUA AAAGCUGGUU 196400
196401 CUUUGGCUAA UUUAGUGCUC AAAGGCUUUC UGCCAGAGAA UAGGGAAAAA 196450
196451 CAAUGGGAUU CUAAAAAUGU AUAUAUGUAU AUAUAUUUAU AGUUUUGGUG 196500
196501 CAAGAUUUAG CAGAAAAAAU AAGGAAAUCA AAGUGCUCAG UGAAAAUGAG 196550
196551 UGUGUUUUUC UGUUUUCUGU UUUGUUUUUG UUUUGUUUCA UUUUGUUUUG 196600
196601 UGAUUGUAUG UGGGGCAUAA AACCUACCAC CGGUGGGGUU UGUGAACAUU 196650
196651 GCUUGACUGU UCACAGUGAA CACUGCCCGC UUAGUUUCAC CUCAUCACAU 196700
196701 CUUCAUGCAA CGAAGAGGGG GAAGAGACUU GACAUUAGCA AAGUGCCUUG 196750
196751 UGCUACAAUU UAAAGGGGGC AUGAUUAAAA GUGCCACCAC AGGAAAGCAG 196800
196801 GAAGGUGGCC GAGUGGUUUC CAAAAGGCCU CACCUGAAGG UAUUUCCGGG 196850
196851 UGGCCCACCU UGGUGCUCUG GCUCACAGCC UCUAGUGCAC ACCAAGCUGA 196900
196901 GUGGCUCAGA AUAACCCAUC AUGGCAACCA GGUUCCCAAG ACGUGGGUAG 196950
196951 AGAAGUUAGA CAUACAUUCU UAUAUCUGUU UGUUUCUACA UUUUUAUACU 197000
197001 GAGGCAUACC UUCCAUGCCA UGCACACCUG UUCAGUGUAG AGCUUGAUAC 197050
197051 AUUUAGAAUA UGUAAACACU GAAUCACUGU CACCCAGAAC AAGAUAUAGA 197100
197101 ACAUGUCCAC CACCCAAAAA UGCUCCCUCA UUCUUCUCCC AGUGAAGGUA 197150
197151 ACCACUCUUC UUGGUCAUUU AUGAUUAUAU ACACGAGGGA GCUUUUCCAG 197200
197201 GGUGAGUAUC AGCACGUCAG AGGAAGCGGG AGGUUCUUUG GAGGGUCUGA 197250
197251 AAUCAGAUGG AAUUGAAGGG UUGGGGAAUC GGGCCAUGGA GAAGCCAACU 197300
197301 GAGUUGCCCC CUCCCACAGU GAUGGCUGGA UUCCUGUCUG CCAGGUUCAC 197350
197351 GGUUGACUCC CUAGAGCACA UUCUAGCUCU UGGCCUGAAC AGGAGAGUUG 197400
197401 UCGGGCUGCA GAACAGAAGG AAGGGCACCC UUUGUCUAGA UGGGCUCUUA 197450
197451 GACAACUGAA AAGGUUUUCA UUCACUGCAC CACAAUCAUG UUCCAAUCCA 197500
197501 GCCUCCCUUC ACGUACACAG CCAGAUCACC UUGAUUCUGA GAUCUGGGUG 197550
197551 UUCCGGACUG CUUUGGUUAU AUAUUGACAG CUUGUUGGCU UACUUUCACA 197600
197601 CAUGGCUAGU CUUCAGAAGA GGUGUGACAU AUUCAAGCCU UGGUGGCAAC 197650
197651 UUUCUCCUUC CUACCAGUCC CUUGGGGUGC AUUGUCAACC CCGUAUCCAA 197700
197701 GCUGCACUAA GUGCUGCCUC UGUUGGGAGU GGUGGGAUUU UUCAUUUGGC 197750
197751 UCCUACGAUG UGCAGUGCUU CCUACAUAUG UCAUGUUACU UAGCAUUCCC 197800
197801 UAGGAUUCUU CAGGGAAGGG AUUAUUAUCC CCGUUUGACA GAUGAGAAUA 197850
197851 UGAAGCAAGU UGCCCAAGGU CACAGAGCUG UUAACUAGCG AGUCUGGGGA 197900
197901 UCAAGGCAGG UCCGUUGAAU CUGAGUGUCC GUGCUCUUUC UAUCACCCCA 197950
197951 CGCUGCCUCU CAGAACGGCC AUAGAUAGUA AUUCAGCUAA GUUUCUGCCC 198000
198001 ACCAGCAACU CGCCCUACUU CCUAUUCAUU CAAGAAGUAU UUAGCCACCA 198050
198051 AAUCAUGAAA UCUCAAAAUU CCGCCACCAG GCUGCUUUAU ACAAGGAGGU 198100
198101 ACUUGAUGUG GGAAAACUCA UUAGAAAACA GUGGACUUUU CAGGGUCAGA 198150
198151 GUGGCAGCUU UGUCCCAGGG UUUGUCAAGU CACCCCAAGU CCUAUUCUUG 198200
198201 GUUAAAUGUC AAUGGGCUGU GUGAGUUCUU CGAGCCUCCA UUAUUAAAGG 198250
198251 AAUGAUCUAU GGUGCUUUCU CUGGAGAAAG CCAAGCACUU UCUAUUCUUG 198300
198301 CUGUUUUCUC AGAAUGAGUA CAUGCCAGUG CUUGUUAACU CAUCCAGAUU 198350
198351 UUCUCUCGAC AUCCCUCUCU CUUGGGCAAU GAGGUGAAGG AGAGAUAUGU 198400
198401 CCUCUUACAA AAUGAGGAGG GAGUCAUCCC AGGUGGAACA UACUUCCCUU 198450
198451 CAAAAGCUUG AUGGCCUAGG CUUUAUUGUA UUAUCCAGGG AAAGUCUGGG 198500
198501 CAGUUGGCCC AGUGCCCGGG CUAGAGUAGU CACUCACUAA AUAUUUGUCG 198550
198551 AAUUAAAUUU AAUUAGAAUA AUUGAAUGAA CACUGGAUUA AGGGGGAUAU 198600
198601 UUCUCUCUGG UAACAACAUG UUCAUGUUUU CUGAAACCCU UAUGGUAUCG 198650
198651 GGGUAUCUGG GAACUGAAAU AGAAAAUAGG AAGCCACUAG AGAAACCUGA 198700
198701 UAGCAGAGUU AAAUGGAUAA GGGCAGAGGA UACACCAAGU UCAAGUUCUA 198750
198751 CAUUAGGUUU GUGAUUUUAG GCAAAUUCCC UUAAUCUCUC UGGGGCUCAC 198800
198801 CCUACUCUGC AAUGUUCAUU UUUUUUUAAA AAGUGAAAAC AGAUGCAUUC 198850
198851 AUUUCUUAGG GCUCUGAUAA UACAUGACCA CAAAUUAGGU GGCUUAAAAC 198900
198901 AAUAGAAGUG GGCUCUCUCA CAGUUCUGAA GGCUAGAAAU CCACCAUGCA 198950
198951 GUGCAAGGGU UGGCUUCUUC UGGAGGGUCU CAGGGAGAAU CGGCUCCAUG 199000
199001 CCUGUCCCCC AGGUUCUGGU GGUGGCUGGC AGCCCUUGGC AUUCCUUGGC 199050
199051 UUGGAGAUGC CCCAUUCCAG UCCCUGCCUC CAGUUUCCCA UGGCUUUCCC 199100
199101 UGUCUCUGUG UGUCUCUGGC UCCAUGUCCA AAUCUCUUCU CAUAAAGAUA 199150
199151 CCAGUUAUAU UGGAUCCAUG GCUGCCCUAA UCCAGUAUGA CUUCAUUUUA 199200
199201 ACUAAUGAAU CUGCAAAGAC CCUAUUUUCA AAUAAGUAAC AUUCUGAGGC 199250
199251 UCUGGGUAGA CAUGAAUUUG GCGGGUGGAG GGAGGGGGCA GACCAUCAUC 199300
199301 GUAACAUAGU AUAAAACAUU ACACAUGAUA AAGCCCUUCU UGUUAUUCCU 199350
199351 GAUACUUUAG UACUGAUGUU GCCUUACAUG AGGGCAUUAA AAAACAAUCU 199400
199401 UGAUAACAUU AUGCUAAGUG AAGUAAGCCA GUCACAGUCA CAAAAAAGAC 199450
199451 AAAUACUCUA UGAUGCCACU CAUAUGAGGU AUGUAGAAGA AUCAAAUCCA 199500
1
199501 CAGAGUCAGA AGGUAGAAGG CUGGUUGUCA GGGGCUGGGG GGAGGGAAGA 199550
199551 AUGAGGGGUU AUUAUUUAAU GCAAUGCUUU UGUUUUGUAA GAUGAGUUUU 199600
199601 GGAAAUUGCC AGCCCAACAA UAUGAAUAUG UACUUAAUGC UGCGGCACUG 199650
199651 UAUGCUUAAA AAUGGUUACG AUGGCCAUGG UUAUGUUACA UAUAUUUUAC 199700
199701 CAUAAUUUAA AAGUUUAAUA AUUUUUAAUU UCAUGAACCA GCCUAGAAAC 199750
199751 CCAACAACUU UUAUAACACU CUUGUUUUUU GUUAAGGAAA CUGCACUCUG 199800
199801 AGUUGCAAAG AACUUUUGCC CUGAGAAUCG UCUGUGAACC GUGUCUGCUU 199850
199851 AUGCCUCAGU GUUUUAUUCU GUUCUCUGUC UUCUUCUUCU CCAAUGCCUU 199900
199901 AGCUAUAACC UGGGCAGUGG UGUGGCAUCC AUCAUGGUGA AUGGCUCCUU 199950
{S Y N L G S G V A S I M V N G S F
199951 CAACGAUGGU CGGUGGCACC GAGUUAAGGC CGUUAGGUGA GUCCCUCCCG 200000
N D G R W H R V K A V R}
200001 CAGCAUGAGG CAGAGCCAGA GCUGAGCAGU GGUGGGAUGU GGUGUCCAGU 200050
200051 UCCCUUGUAG UCCCACUGUC CUGUUCCCCA ACUUUGCCUG GCAUCCUAGU 200100
200101 UACCCCUGAU CCAGGGCAUU CAGGGAAUUU UCUACCAAUU CCCGCUGUGC 200150
200151 CCUACAUUGA CACUAUCAGG CCAGGGAAAC UGAACCCCCA AACCUUCAUU 200200
200201 AAGCAGUAAC CUUCUGGAGA AGAAACCUUU UGAUGGCUGA UCUGGAAGAA 200250
200251 CCUUGAGAGU UCAGUGUAUG UGGACUUUAA AGAAUGUUUG GGCCGGGCAU 200300
200301 GGUGGCUGAC ACCUGGAAUA CCAGCACUUG GGGAGGCCGA GGUGGGUGGA 200350
200351 UCACCUGAGC UCAGGAGUUU GAAACCAGCC UGAGUUACAU GGCGAAACCC 200400
200401 UGUCUCUACA AAAAAUACAA AAAUUGGCUG GAUGUGGUGG CACACGCCUG 200450
200451 UAAUCCUAAC UACUCGGGAG GCUGAGGUGG GAGGACCGCU UAAGCCUGGG 200500
200501 AGGUGGAGGU AGCAGGAUCA UGCCAUUGCA CUCCAGCCUG GGUGACAGAG 200550
200551 UGAGACCCCA UCUCAAAAAA AAAAAAAGAC UUUCAAAUCU CAUUGUACAG 200600
200601 GCAAUCCUCC CCCCUCCCUC UGGCUUUUUU UUGUUUGUUU UGUUUUGAGA 200650
200651 CAGGUUCUCG CUCUGUCACC UAGGCUGGAG UACAGUGGUG UCAUCAUGGC 200700
200701 UCAGUGCAGC CUCGCUUGAC CUCCCAGGCU CAGGCAGUCC UCCCACUUCA 200750
200751 GCCUCUUGAG UAGCUGGGAC CACAGGUGUG CACCAUCUGC CUUGCUAUGU 200800
200801 UGCCAGGGCU GGUCUCAACC UCCUGGCCUC AAGUGAUUCU CCCACCUUGG 200850
200851 CCUCCCAAAG UGUUGGGAUU ACAGGCAUGA GCCACUGCAC CUGGCCACUU 200900
200901 UUUUUUUUUU UACACAUUAC CUAAACCUUA GAACCUGACU GUAUUUCACU 200950
200951 CAGCCCCAAU UACAUAUCUC CCCCAUCACA GAGGUAAUCA CCAUCCUGAC 201000
201001 UUCUGAUUAA CUUUGGAUGA AUCAUUCCUU UGCUCUUCUU UAUAUAAUAG 201050
201051 UUUUACUAUU AAUACCUUUG UCCAUAUUUC UAACAACAUA UUUUCAGAAA 201100
201101 CGAAAUAGCA GGCUGAAACU UAGAAAUGUC AAUCUCGCAA GUUAGAUGAA 201150
201151 GGUCCCAGGA GAAGAUAAGC UGAAAUGAAG GUCUGGUUGG GGUUCCCUGA 201200
201201 GAAUUUAUCA UAACCCUUUC UGGGGAAGCC AGUGGGUAAA GUCAUGAGUG 201250
201251 AGGCCUGGGA AACAUGGCGC CCACCAUGGC UACUUUCCUA CUCAGCUCCC 201300
201301 AUAUAGGCUG CAAUGGGGAG AGACUUGCUG GGCCCCCAAC CCCUGGCUGC 201350
201351 UGGGCCCCCA ACCCCUGGCU GCUGGGCCCC CAACCCUGGC UGUUGGGCCU 201400
201401 GCCUUUGAAA CCCUAGAGGA AAUGGGGAUA CAGAGGCAGA UCUGUGCCUC 201450
201451 UCAGCUUCCC AGAUGGUCUA GAAAGCCCUU GAGACAGAGG UUGAUUUUGA 201500
201501 UGAAGUCUCA ACUCUAACUU UCUGAAAAAA GAAAUGUUGU CCCAUCAUGA 201550
201551 AUAUCCACAU GCUUGGAUUU CAAAUAGUUU CUAGACUACA AGUUAAAAAU 201600
201601 UCAGAGCCCA GCCUAACUCC AAAAUACUCC AAACUCUAUG GCUUCUAACU 201650
201651 UCUUCAUUUC UGCCUCUUAC CCAUCUUUAA AGGGGCUUGG CCAGAGACAU 201700
201701 CCAAAGGAAU AUGAAAUGCU UGAGCUCUUU ACCUCUAACC ACACUUGAUC 201750
201751 CCUACAAAUC CCCACCCUGG GAACAUCAGG GAACAACACC CUUCUCCCAG 201800
201801 UUUCCUUGGG UGGAGAUCAU UGGUAGAAUA CUCACACAUU GUGGAAUAAU 201850
201851 UUUUAAGCCU UCCCAGUUGU UGUUGGGGUU UGAUUAUGUG UAUCAAGAUA 201900
201901 CACUCUGGUG AGGAUACCAG GCACUUCCUA GACAUCUAAG GAAACUGAUG 201950
201951 UUAAAUGAUC UUCCCCUAGA CUAUACAACU GUUUGUGGGA AAAGCCAAGA 202000
202001 UUAGAAUCCC AGCUCAAAGC CCUUUCCAUC CUACCCCAUG AUGAAACCCA 202050
202051 CCCAAAGCUA GGAUUUCAGA UGUUUGGGAG GGAUAAGGCA GUGGAAUGUU 202100
202101 CUACAGGAAG AAUUUCACAU GUCAGAGUGU CAAGCUGGGC ACCAUGCAGA 202150
202151 UGGCUUAGCA GACUUGGCUU UUCCUGUUGG CAUCAUGGAU ACCUCUGCUG 202200
202201 GUGGGUCUUA GGUUGCAAUG AGGGCUGAAC AGAAGGAGUC GAGCCCAGGA 202250
202251 ACUAGAUGAA UGGGAGGAUU CCAGCAGAUA CUGUGAGUUG UGAGCAGACA 202300
202301 GGCCUAGAAG GGAAGAGUUC UCAGGGGGAA CUGGGUCAAG GCCAUGGAUA 202350
202351 UCAAUUAUGG CAAGAAGGAU UGAGCAGAUA CCUUAAUUCU CUGUAGCAGG 202400
202401 CUCCAGGGUU AGAGAUAGGA GUGUCAAUGA AAAGGAGAUU GCCCAGGGGG 202450
202451 CCUUGCUUUG GACAGUGUCU UGCUCUGGGG CAUCCUGCUC UUGCAGGCAU 202500
202501 UAAUCCCAGC AGAAAAGAGA AAAUAAAUUC CAGUUUAUUA AACAUCUCCA 202550
202551 GUUGCCAGGU ACUUUUCAUA CUUUGUCUCA AUAUUCACAG CAACUUAGGU 202600
202601 UUUAUAAUCU UCAUUUUAUG GAUAAAAAUG AUAAUGAUAU UGAUAACAAU 202650
202651 AACAACACAC UCCUCUACCA GUCUUUAUAG AGCAAGAUGU GUAUCAGGUA 202700
202701 UCAUGCCCUG UGCUUUGUAC GCAUAACAUC UGAUCUCCAC AAUAAUCUCG 202750
202751 GGAGAUGGGC AUAGCUAUUC CCAUCUUAGG UGAGGAUGCU GAAGCUCCAC 202800
202801 AGAUUCACUG UUCAUUCAUC AUCUGGGAUG AGCCUUAUAU CAUUCCAGAC 202850
202851 ACAGGAGAUA CCUCAUUGAA GAAAAUUAAC AUCCUUGCCU UGAUGGUCUU 202900
202901 GCAUUCUAAU GGGAAGCAAC AGACAAUAAG UAAUAAACAU GAUAAAGAAG 202950
202951 CAUGUUAUUA UGCUAGAAGG UGAUGCCACA UUUUUUCAAA UCUAAGAUGC 203000
203001 CAUUGAUUAU AAGGUAUAUC UUCAUUUUAG AUAUAAAAAA UGAAAAACUC 203050
203051 UUAGACUUUA UGAACUAGAG UAAGUAGAAA AAAAUGGAAU AUUUUAGAGU 203100
203101 AAUUAAUUUU UUUUUUUAAA GGCAGGGCAA GCAAGGCAAG CUGUUGCGGG 203150
203151 UUCUGCCUGU CACAGCAUUC AGAUACAGGA UUCUAAGAAA GCACUUCCCA 203200
203201 AAUGGGAAGU UUGUGGUCUC AAAGAUGGGG ACAGAACAAG AGAAAGUUCU 203250
203251 GUAAAUCUCU AGAAGAGUUG CUAUCAAGAA GUGAAGCCUG AGUGAGUCCA 203300
203301 CCCCCUAGUG CUAUAGAAGC AAAUGUAUUU GCUUGAACAA GGCUCAUGGG 203350
203351 GCUGGAUAGG UUUGAAAAAU AGCUUUGAAA ACUACAAAGC CCUUGCCACC 203400
203401 AAUGAACACC UCCCUCUUCC UGUCGUCAGA GUCACUUUAG GGCUCUGUGG 203450
203451 GUCCUUUAGA AACUUCUGAG CCACUGGCCG GGUGCAGUGG CUCACGCCUG 203500
203501 UAAUCCCAGC ACUUUGGGAG GCCGAGGAGG GCGGAUCACU AGGUCAGGAG 203550
203551 AUCGAGACCA UCCUGGCUAA CGUGGUGAAA CCCCGUCUCU ACUAAAAAAA 203600
203601 AUACAAAAAA UUAGCCGGGC GAGGUGGCGG GCGCCUGUAG UCCCAGCUAC 203650
203651 UCGGGAGGCU GAGGCAGGAG AAUGGCGUGA ACCCCGGGGG GCGGAGCCUG 203700
203701 CAGUGAGCCG AGAUCGCGCC ACUGCACUCC AGCCUGGGCG ACAGCGGGAC 203750
203751 UCCGUCUCAA AAAAUAAAAU AAAAUAAAAU AAACAGAAAC UUCUGAGCCA 203800
203801 GUCUUCCCAU CGAAUGAUCU UAUACCUACA AAAACUGCUU CAUUGGCUUC 203850
203851 UCAUUGUACU UAGAAUCCCA GCUCCCCAUG GCUUCCCAUG CCUCGCCACA 203900
203901 AGCUCUCCUC CCCUGGGCUU CACCUGAAAU UUCUUCCCUG GCCCGCUGUC 203950
203951 ACCUUCAGGA UAAAUUCUCA ACUCCUUACA AGCGGUUGAC CGUUUGCUUG 204000
204001 GGGCUUCACC UUUCCCAGCC CCAGUGUUCU GUGAGUUCCA UCUGUGCUAA 204050
204051 CCCCUGCUCU UUCUCUUUGC UGUUGUUGCU UUCUCUGUUU GCAUAGCCUU 204100
204101 CUCCUUCACU UGACUUACCU ACCCAGCCUA CAAGACUCAU UUUGGACAGA 204150
204151 AUCUCCUCUG AGCAGCUUUU UCUGACCAUC UCUCUAAUAA CUGUCCUCUC 204200
204201 UCUAGUCUAA GUUAGGCGCU GCUCCUCUGG UGUAAUUCCA CAGCACCCUU 204250
204251 GUGGUCUUCG CCGUGGAGUG CUGGCACUGU GUUGUCAUUC ACAGUUUGAC 204300
204301 UUUUUGUCUU CCUCAGUAGA CCACAGGCUC CUGAGGGCCA CACAUUUGCU 204350
204351 UUUUGCUUUG AUUUCUGCAG CCCCAUCAUU UAGCACAGUA CCUGGCACAU 204400
204401 AGUGUGUCCU UUAAUACAUU UGUAUUGAAA UGAAUGAAUG AUUGAAUGAA 204450
204451 CUCCAAAAAU GCCAGGCUUU UUGUUCUUUU UUGUUUUGGU GUUUUGCAGG 204500
204501 GAUGGCCAGU CAGGAAAGAU AACCGUGGAU GACUAUGGAG CCAGAACAGG 204550
{D G Q S G K I T V D D Y G A R T G
204551 CAAAUCCCCA GGCAUGAUGC GGCAGCUUAA CAUCAAUGGA GCUCUGUAUG 204600
K S P G M M R Q L N I N G A L Y
204601 UGGGUAAGUG ACCGACCCUC GACCAAAGCA AAAUUAGGCC AGUGCUUUUC 204650
V G}
204651 UUGUUAGUCU UCCAUUUGCU GUGCCGAGGC UAUGUACUUU GCUGGAUCAA 204700
204701 AUACCUGUAA AUCAGGAAGC CCUCCAGAUA UUCCAUUCCU UCAUUUUCUG 204750
204751 AACUGCUGAC UCAUGGCUGA GGGGGCAGGA AGGGCUCCCU UCGAUGCUUU 204800
204801 UAUGCUUUGG ACAGAUCCAC CAGGAAAACC AGGCUUUUCU UGUUUAUAGA 204850
204851 ACAGGAACCU GCUAAAUAUA GCUCCAUGAG UUCUCUCUGA CAAAACGGGA 204900
204901 CCUGUCUUUC UUUCCCCUUG CAGAAUAGAA UGACUAGUAU UUCUGUAAAU 204950
204951 GGCUUAUUAU AAUUAAUUCA CUAGUGCAGA CACAUAAAAA UGAAAAGCUA 205000
205001 UUUUUAUCUA UAUGAUAUUU UCUAUUGAAA GCAUUCGACA UCAGUGCAUU 205050
205051 UGUUUUGGUU UAAGAUGACA UCACUUCUAA CUACACACUG CAUUCUGUUG 205100
205101 ACAUUAUACC ACACUUCAAA AUUUACUAGA CACUAUUUGG UCUCAAGGUG 205150
205151 GUCAGUUGGG CCAGAAAUCA CACAUGAGGA AUGAAUUUAU AGCUUUUGAU 205200
205201 UGUGUAAAAA CUGAUCCAAG UCAAUCUGUU CCUUCAAGGA UAAUUAUAAA 205250
205251 AUUGAGAGAG GUGAGGUACU GAGCAGCUCA AGGGGCCCAC AGCCCUCACA 205300
205301 UGUCCCAUGA AUCAAGGGAU GCCUUGGCCA GCAGCCAUUC AAGUGCCCCA 205350
205351 AACUGGAACC CCGACCUUGC CCUGCGGACA CCUGUCCUUU GGCUCACCUC 205400
205401 AUCUCCCUCU UGCUUCCUGG CAGGUGGAAU GAAGGAAAUU GCUCUGCACA 205450
{G M K E I A L H
205451 CUAACAGGCA AUAUAUGAGA GGGCUCGUGG GCUGUAUCUC UCACUUCACC 205500
T N R Q Y M R G L V G C I S H F T
205501 CUGUCCACCG AUUACCACAU UUCCCUCGUG GAAGAUGCCG UGGAUGGGAA 205550
L S T D Y H I S L V E D A V D G K
205551 AAACAUCAAC ACUUGUGGAG CCAAGUAACA CCAGCUGGCC UUGUCCAAGG 205600
N I N T C G A K}
205601 GACAGAGCCU UCUAUUCUGA GAAUCCCAGG GGCCCUCAGA CCCUGCCUGA 205650
205651 UGCUAUAUGC AGAGGCCCAG GGACCAGGUG UGUUUCCUCU CACCAAGAAG 205700
205701 AAAGUACACA CUGAUGAGAA ACUGAGAACC AAGACAGGCA UCCCUGGGUG 205750
205751 GCCUUUCCUG CUGACACUCC ACGAGCUGAC CCAGCAGAAU UCUCUGUGUA 205800
205801 GGAAGCAUCG GACUUUGUCC AUUGAAUAUG UAGCGGCUGC CAGAGAUCAC 205850
205851 ACAUCAAUGC AAAUUCCAGA GCCUGUCUGC UAUAGCUCAG UGACUGUGUU 205900
205901 GUGAUUCAUA GUACAUUAAA AAGAGAGAGA GAGAGAAAGA AUCCCACAGG 205950
205951 GCACUAUUAA AAUACUUCUC UCCUUCCCUG ACUCAUGACA CUCUUCCUGA 206000
206001 CAGCAGAAUG ACUGUGUGAC CUUGAACUUC ACAUUUCCCA CAUUGGCCCU 206050
206051 UGGAUUGUUC GGAUUAACCC CUUCCACUCC UCACUGGCUG GUUCACUGUG 206100
206101 UUCUGACUAG UCCAUAAAAA UAAAGAUGGA AGGAGAUCAA ACACAGAAUC 206150
206151 AUAAUCAUAA UGCGGCCCCC UUCCCCAGAG CUUACCUCGA AUGUGAAAUC 206200
206201 CCUACUUCUU AUAAUGCAGA GUUAAGGAGC UGAGCCCCCA UGAUUUUGUA 206250
206251 GCUGUACUUU UGUAUGUGUA UAUUUUUAUA GCUGCAGAUU GUCCACACAG 206300
206301 UAUACUUUUG GAAGUUUGGG UGGAUGACUC UGAAUUCUUG CACACCUUUC 206350
206351 CUAAAAAUUU CUCCCAAGAG AGACUUGUUU GGGCCUUUUG UGGUGUCAGU 206400
206401 GGAAUGGAUA GGUAACUUGG GUGGGCAACU UGGGGAGCUG ACCAUUCUCU 206450
206451 UUUGGUAAAU GUUGACGGCU CAAGAGGAUG AAUAUGAAGC UUUCCAAGAU 206500
206501 AAGCAGAUUA AAAGGAACAU GUGUUACCGA GGUAGGUCAC UGUCAUUUUU 206550
206551 GUUUUAAGAG UUGGGGGGAG UAUCUAUAGU AAACUUGAAU AAAGGGGACA 206600
206601 AAGCUAGAAC UUAUUCAUUC AUUCAUUCAC UUAUGGAGUU GUUACUGAUU 206650
206651 UUGCGGAGGU CAGGUUCAUA CCAAUGGACA CUAAUACAAU CAGUGUUCCC 206700
206701 AAGGCUGUGC AGGGGUGGGG GGACAUGCUG UCAGGAUGGU CUGAGCAUCU 206750
206751 GGGUGAGAAC CAGAGAAACA GGACUUCUUC CUUCUGUACC AUGAGCUGUG 206800
206801 UCCCUUUACU AUGCAAGCAC AUGACCCCAG AGACAGCUGG UUCACUGGCA 206850
206851 GAUCCCCAUG AUGGACUUAC UAAGGGAAAG GUGAGAUGAA CACUGCCCCC 206900
206901 AAGGAGGGGG UGAAAUAUGA UCUAACUUAU GCAAGAGCCU AUAAUUAGUC 206950
206951 CCAGUCUCGA CUCUACAUUU GUUUGUGCAG CAUUCAUUCA GCAAAGACUU 207000
207001 UUGGGGUUUG UGCAAGGCAC AGUUUUAAGC ACAUAAUGUA AUUCUAAAAG 207050
207051 AUGAAUAAAC UAGAGAGGUU CA 207072
