Computer Science, 3rd Year (Spring 2018)

Finding Introns and Exons Computationally

Step 1. On the NCBI website
(National Center for Biotechnology Information: www.ncbi.nlm.nih.gov)
students search for a GENE and its respective PROTEIN (RefSeq) product.

Step 2. Using the CODON Table (left),
students write a program that TRANSLATES DNA to PROTEIN.

Step 3. Using FRAMESHIFTS of 0, 1 and 2, the program translates the entire gene,
and matches the longest subregions of the protein to corresponding
regions of the translated gene, and then back to the gene itself.
This process locates the gene's EXONS (protein coding regions).

Step 4. Finally, students output a MAP to show both the gene's EXONS
and the intervening INTRONS (non-protein coding regions).

Dopamine Receptor D4 (DRD4)
 
Pikachurin
 
Insulin
 
MCM6
 
HBA1
 
Glutathione
S-transferase P